Chediak-Higashi syndrome
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Summary of Chediak-Higashi syndrome
Chédiak–Higashi syndrome is a rare autosomal recessive disorder that arises from a mutation of a lysosomal trafficking regulator protein, which leads to a decrease in phagocytosis. The decrease in phagocytosis results in recurrent pyogenic infections, partial albinism, and peripheral neuropathy.
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Immune system
Pathology
General infections
Hypersensitivity reactions
Type I hypersensitivity
Food allergy
Anaphylaxis
Asthma
Type II hypersensitivity
Immune thrombocytopenic purpura
Autoimmune hemolytic anemia
Hemolytic disease of the newborn
Rheumatic heart disease
Myasthenia gravis
Graves disease
Pemphigus vulgaris
Type III hypersensitivity
Serum sickness
Systemic lupus erythematosus
Poststreptococcal glomerulonephritis
Type IV hypersensitivity
Graft-versus-host disease
Contact dermatitis
Transplants
Immunodeficiences
X-linked agammaglobulinemia
Selective immunoglobulin A deficiency
Common variable immunodeficiency
IgG subclass deficiency
Hyperimmunoglobulin E syndrome
Isolated primary immunoglobulin M deficiency
Thymic aplasia
DiGeorge syndrome
Severe combined immunodeficiency
Adenosine deaminase deficiency
Ataxia-telangiectasia
Hyper IgM syndrome
Wiskott-Aldrich syndrome
Leukocyte adhesion deficiency
Chediak-Higashi syndrome
Chronic granulomatous disease
Complement deficiency
Hereditary angioedema
Asplenia
Immune system organ disorders
Immune system pathology review
AssessmentsChediak-Higashi syndrome
Chediak-Higashi syndrome
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Flashcards
Chediak-Higashi syndrome
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USMLE® Step 1 style questions USMLE
3 questions
Preview
A 12-year-old girl comes to the pediatrician’s office because of a recently diagnosed streptococcal infection. She has a history of repeated bouts of staphylococcal and streptococcal infections throughout her life, for which she had been prescribed antibiotics each time. Physical examination shows features similar to defective melanin synthesis. Which of the following immune deficiencies is most likely present in this patient?
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