Clonorchis sinensis

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Clonorchis sinensis

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USMLE® Step 1 style questions USMLE

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A 41-year-old man is hospitalized for cholangitis. Two months ago he traveled around eastern Asia and ate several meals consisting of raw fish. Temperature is 38.3°C (100.9°F), blood pressure is 138/80 mmHg, and pulse is 85/min. Laboratory studies reveal an alkaline phosphatase of 415 U/L (reference range: 20-70 U/L) and total bilirubin of 4.1 mg/dL (reference range: 0.1-1.0 mg/dL). Both liver biopsy and serum tests for Echinococcus granulosus are negative. A stool sample is collected and found to contain several eggs. Which of the following pathologies is most likely responsible for this clinical presentation? 

External References

First Aid

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Biliary tract disease p. 402

Clonorchis sinensis p. , 158

Cholangiocarcinomas

Clonorchis sinensis p. , 157, 158

Clonorchis sinensis

cholangiocarcinoma p. 222

diseases association p. 158

trematodes p. 157

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Summary

Clonorchis Sinensis is a liver fluke that is found in East Asia and Southeast Asia. It is a human liver parasite known to cause clonorchiasis, an infection characterized by right upper quadrant abdominal pain, jaundice, fever, diarrhea, and even death. It is contracted by ingesting raw or undercooked fish. Clonorchis sinensis infection can complicate into cholangitis and cholangiocarcinoma.