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Clostridium botulinum (Botulism)
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Clostridium botulinum p. , 136
exotoxin production p. 130
food poisoning p. 175
spore formation p. 129
therapeutic uses p. 136
Clostridium botulinum as cause p. 136
Clostridia, as a family, are obligate anaerobes, meaning that oxygen is toxic to them.
In nature, they thrive in deep, compact soil, and when they feel the stress of fresh oxygenated air, they often produce spores, which are metabolically inert and extremely resilient to the environment.
Then, when environmental conditions improve, the spores are able to sprout into fully fledged Clostridia.
When doing a Gram stain, Clostridium botulinum stains purple, or Gram positive, and it’s a bacillus, meaning that it looks like a big cylinder or rod under the microscope.
Historically, to preserve foods, processes like sausage making and canning became popular.
Unfortunately, since these environments block out air, if a Clostridium botulinum spore gets in during the food preparation process, it can grow and produce botulinum toxin, contaminating the food.
In fact, this is how Clostridium botulinum gets its name, since botulus means sausage in Latin.
Now, nerves that use the neurotransmitter acetylcholine are those we use for muscle control.
Upon ingesting a contaminated food product, botulinum toxin works by binding specifically to these nerves, inhibiting muscle contraction.
The toxin comes in eight distinct types, named type A, B, C, D, E, F, G, and H, and they vary in their toxicity.
The neuron takes in the botulinum toxin by endocytosis, creating a small vesicle that floats within the neuron’s cytoplasm.
Clostridium botulinum is a gram-positive, rod-shaped, anaerobe, spore-forming bacterium known to produce botulinum toxin, which causes botulism. Botulism can happen after eating food contaminated with the toxin or by breathing in the toxin. The symptoms of botulism include weakness, dizziness, double vision, drooping of the eyelids, trouble speaking or swallowing, and muscle paralysis. If it's not quickly treated, botulism can lead to death.
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