Colorectal polyps and cancer: Pathology review

00:00 / 00:00

Preguntas

Preguntas del estilo USMLE Step 1

de completadas

A 5-year-old boy is brought to the physician by his mother due to excessive fatigue over the past 2 months. The mother has occasionally noticed blood in the toilet bowl after the patient defecates. There is no significant family history of cancers. The patient's temperature is 37.0°C (98.6°F), pulse is 96/min, and blood pressure is 110/70 mmHg. Physical examination shows conjunctival pallor. No abnormal skin pigmentation is noted. Laboratory results are as follows:

 Laboratory Value  Result 
 Hemoglobin  9.7 g/dL 
 Hematocrit  35% 
 Mean corpuscular volume (MCV)  74 μm3 
 
Colonoscopy is performed and reveals seven polyps throughout the gastrointestinal tract; subsequent biopsy reveals hamartomatous mucosal polyps. Genetic testing is performed and reveals a mutation in the BMPR1A gene. Which of the following is the most likely diagnosis in this patient? 

Transcript

Watch video only

At the gastroenterology clinic, there is a 63-year-old Caucasian male, named Neil, who's complaining about progressive fatigue and weight loss in the last 6 months. Laboratory findings reveal positive fecal occult blood test and iron-deficiency anemia. At the same time, an 18-year-old Caucasian male, named Brendon came in for a colonoscopy screening. He was concerned after learning that both his grandfather and uncle were diagnosed with colon cancer in their early thirties. His doctor detected more than one hundred polyps on colonoscopy.

Now, both people have some form of colorectal polyps or cancer. But first let’s start with colorectal polyps, which are overgrowths of epithelial cells in the colon or rectum. They are subdivided into non-neoplastic polyps, such as hamartomatous polyps, hyperplastic polyps, inflammatory pseudopolyps, mucosal, and submucosal polyps; and neoplastic polyps, which include adenomatous and serrated polyps.

Hamartomatous polyps are solitary, disorganized masses that contain normal tissue found at the site of the polyp. These polyps can occur sporadically, or in genetically inherited conditions, such as juvenile polyposis syndrome or Peutz-Jeghers syndrome; and they have mild malignant potential.

Next, hyperplastic polyps, are the most common polyps and they are small and typically located in the rectosigmoid region. Usually, these polyps are benign lesions, but in rare cases, they can evolve into serrated polyps, which have malignant potential.

Inflammatory pseudopolyps are multiple benign pseudopolyps that occur during regenerative and healing phases in chronic inflammation, and they are most commonly seen in inflammatory bowel disease.

Mucosal polyps, which are clinically insignificant, are usually small, less than 5mm, and they look similar to surrounding normal mucosa. On the flip side, submucosal polyps can include lipomas, leiomyomas, fibromas, or other lesions.

Fuentes

  1. "Robbins Basic Pathology" Elsevier (2017)
  2. "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
  3. "Sabiston Textbook of Surgery" Elsevier (2016)
  4. "Update on genetic predisposition to colorectal cancer and polyposis" Molecular Aspects of Medicine (2019)
  5. "Hamartomatous Polyposis Syndromes" Surgical Clinics of North America (2008)
  6. "Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management" Journal of Gastroenterology (2012)
  7. "Management of Serrated Adenomas and Hyperplastic Polyps" Clinics in Colon and Rectal Surgery (2008)
  8. "Pseudopolyps in inflammatory bowel diseases: Have we learned enough?" World Journal of Gastroenterology (2017)
  9. "Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk Factors" Clinics in Colon and Rectal Surgery (2009)
Elsevier

Copyright © 2024 Elsevier, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

Cookies are used by this site.

USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME). COMLEX-USA® is a registered trademark of The National Board of Osteopathic Medical Examiners, Inc. NCLEX-RN® is a registered trademark of the National Council of State Boards of Nursing, Inc. Test names and other trademarks are the property of the respective trademark holders. None of the trademark holders are endorsed by nor affiliated with Osmosis or this website.

RELX