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Common variable immunodeficiency

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Common variable immunodeficiency

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High Yield Notes
10 pages
Flashcards

Common variable immunodeficiency

9 flashcards
Questions

USMLE® Step 1 style questions USMLE

2 questions
Preview

A 27-year-old female comes to the clinic with an upper respiratory infection. She has had repeated respiratory and gastrointestinal infections over the last several months, including infection with organisms she has received vaccines for. She has a past history of sarcoidosis and alopecia. She does not take any medications. Serum laboratory studies show an absence of plasma cells and low levels of all immunoglobulins. Which of the following is the most likely diagnosis?

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Summary
Common variable immunodeficiency is the most commonly diagnosed primary immunodeficiency that results in a defect in B-cell maturation. It is characterized by low antibody and plasma cell levels. It usually presents after age 2 and may be considerably delayed. There is an increased risk of autoimmune disease, bronchiectasis, lymphoma, and sinopulmonary infections.