Common variable immunodeficiency
Videos
Notes
Common variable immunodeficiency
Pathology
Hypersensitivity reactions
Anaphylaxis
Asthma
Food allergy
Type I hypersensitivity
Autoimmune hemolytic anemia
Goodpasture syndrome
Graves disease
Hemolytic disease of the newborn
Myasthenia gravis
Pemphigus vulgaris
Rheumatic heart disease
Type II hypersensitivity
Poststreptococcal glomerulonephritis
Serum sickness
Systemic lupus erythematosus
Type III hypersensitivity
Contact dermatitis
Graft-versus-host disease
Type IV hypersensitivity
Immunodeficiences
Asplenia
Common variable immunodeficiency
Hyperimmunoglobulin E syndrome
IgG subclass deficiency
Isolated primary immunoglobulin M deficiency
Selective immunoglobulin A deficiency
X-linked agammaglobulinemia
Adenosine deaminase deficiency
Ataxia-telangiectasia
Hyper IgM syndrome
Severe combined immunodeficiency
Wiskott-Aldrich syndrome
Complement deficiency
Hereditary angioedema
Cytomegalovirus infection after transplant (NORD)
Post-transplant lymphoproliferative disorders (NORD)
Chediak-Higashi syndrome
Chronic granulomatous disease
Leukocyte adhesion deficiency
Immune system pathology review
Blood transfusion reactions and transplant rejection: Pathology review
Immunodeficiencies: Combined T-cell and B-cell disorders: Pathology review
Immunodeficiencies: Phagocyte and complement dysfunction: Pathology review
Immunodeficiencies: T-cell and B-cell disorders: Pathology review
Assessments
Common variable immunodeficiency
Flashcards
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USMLE® Step 1 questions
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High Yield Notes
10 pages
Flashcards
Common variable immunodeficiency
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Questions
USMLE® Step 1 style questions USMLE
of complete
| Laboratory value | Result |
| Complete blood count | |
| Hemoglobin | 12 g/dL |
| Leukocyte count | 10,100 /mm3 |
| Platelet count | 200,000/mm3 |
| Immunoglobulins | |
| IgG | 250mg/dL |
| IgA | 24 mg/dL |
| IgM | 15 mg/dL |
| IgE | undetectable |
| CD4/CD8 ratio | 2 (normal, 1-4) |
Chest x-ray reveals a right lower lobe infiltrate. Which of the following is the most likely diagnosis in this patient?
External References
First Aid
2022
2021
2020
2019
2018
2017
2016
Common variable immunodeficiency (CVID) p. 114
Summary
Common variable immunodeficiency (CVID) is an immune system disorder that impairs your ability to fight infection. It's characterized by low serum levels of all immunoglobulins. People with CVID may present with repeated infections, such as sinus infections, ear infections, pneumonia, and blood infections. They're also at higher risk for other problems, such as autoimmune diseases (diseases where the body mistakenly attacks its tissues), like autoimmune hemolytic anemia, and can also have cancer and gastrointestinal issues. CVID is diagnosed through blood tests through quantitative measurements of the immunoglobulins.
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