Common variable immunodeficiency

3,888views

Videos

Notes

Common variable immunodeficiency

Watch later

Playlist

Abdominal hernias

Small bowel ischemia and infarction

Familial adenomatous polyposis

Peutz-Jeghers syndrome

Juvenile polyposis syndrome

Colorectal polyps

Colorectal cancer

Irritable bowel syndrome

Diverticulosis and diverticulitis

Appendicitis

Biliary atresia

Jaundice

Cirrhosis

Portal hypertension

Hemochromatosis

Wilson disease

Non-alcoholic fatty liver disease

Cholestatic liver disease

Autoimmune hepatitis

Alcohol-induced liver disease

Alpha 1-antitrypsin deficiency

Primary biliary cirrhosis

Primary sclerosing cholangitis

Hepatitis

Neonatal hepatitis

Reye syndrome

Benign liver tumors

Hepatocellular carcinoma

Gallstones

Biliary colic

Acute cholecystitis

Ascending cholangitis

Chronic cholecystitis

Gallbladder cancer

Acute pancreatitis

Chronic pancreatitis

Pancreatic cancer

Congenital gastrointestinal disorders: Pathology review

Esophageal disorders: Pathology review

GERD, peptic ulcers, gastritis, and stomach cancer: Pathology review

Inflammatory bowel disease: Pathology review

Malabsorption syndromes: Pathology review

Diverticular disease: Pathology review

Appendicitis: Pathology review

Gastrointestinal bleeding: Pathology review

Colorectal polyps and cancer: Pathology review

Pancreatitis: Pathology review

Jaundice: Pathology review

Viral hepatitis: Pathology review

Cirrhosis: Pathology review

Iron deficiency anemia

Beta-thalassemia

Alpha-thalassemia

Sideroblastic anemia

Anemia of chronic disease

Glucose-6-phosphate dehydrogenase (G6PD) deficiency

Autoimmune hemolytic anemia

Sickle cell disease (NORD)

Aplastic anemia

Folate (Vitamin B9) deficiency

Vitamin B12 deficiency

Acute intermittent porphyria

Hemophilia

Hemolytic-uremic syndrome

Von Willebrand disease

Disseminated intravascular coagulation

Heparin-induced thrombocytopenia

Antithrombin III deficiency

Factor V Leiden

Protein C deficiency

Protein S deficiency

Antiphospholipid syndrome

Hodgkin lymphoma

Non-Hodgkin lymphoma

Chronic leukemia

Acute leukemia

Myelodysplastic syndromes

Polycythemia vera (NORD)

Myelofibrosis (NORD)

Essential thrombocythemia (NORD)

Waldenstrom macroglobulinemia

Microcytic anemia: Pathology review

Non-hemolytic normocytic anemia: Pathology review

Intrinsic hemolytic normocytic anemia: Pathology review

Extrinsic hemolytic normocytic anemia: Pathology review

Macrocytic anemia: Pathology review

Heme synthesis disorders: Pathology review

Coagulation disorders: Pathology review

Platelet disorders: Pathology review

Mixed platelet and coagulation disorders: Pathology review

Thrombosis syndromes (hypercoagulability): Pathology review

Lymphomas: Pathology review

Leukemias: Pathology review

Plasma cell disorders: Pathology review

Myeloproliferative disorders: Pathology review

Abscesses

Type I hypersensitivity

Food allergy

Anaphylaxis

Asthma

Type II hypersensitivity

Myasthenia gravis

Pemphigus vulgaris

Type III hypersensitivity

Serum sickness

Systemic lupus erythematosus

Poststreptococcal glomerulonephritis

Type IV hypersensitivity

Graft-versus-host disease

Contact dermatitis

Transplant rejection

Cytomegalovirus infection after transplant (NORD)

Post-transplant lymphoproliferative disorders (NORD)

X-linked agammaglobulinemia

Selective immunoglobulin A deficiency

Common variable immunodeficiency

IgG subclass deficiency

Hyperimmunoglobulin E syndrome

Isolated primary immunoglobulin M deficiency

Thymic aplasia

DiGeorge syndrome

Severe combined immunodeficiency

Adenosine deaminase deficiency

Ataxia-telangiectasia

Hyper IgM syndrome

Wiskott-Aldrich syndrome

Leukocyte adhesion deficiency

Chediak-Higashi syndrome

Chronic granulomatous disease

Complement deficiency

Hereditary angioedema

Asplenia

Thymoma

Ruptured spleen

Immunodeficiencies: T-cell and B-cell disorders: Pathology review

Immunodeficiencies: Combined T-cell and B-cell disorders: Pathology review

Immunodeficiencies: Phagocyte and complement dysfunction: Pathology review

Vitiligo

Albinism

Acne vulgaris

Folliculitis

Rosacea

Hidradenitis suppurativa

Atopic dermatitis

Lichen planus

Pityriasis rosea

Psoriasis

Seborrhoeic dermatitis

Urticaria

Actinic keratosis

Epidermolysis bullosa

Bullous pemphigoid

Erythema multiforme

Stevens-Johnson syndrome

Pressure ulcer

Sunburn

Burns

Frostbite

Cellulitis

Erysipelas

Impetigo

Necrotizing fasciitis

Human papillomavirus

Varicella zoster virus

Poxvirus (Smallpox and Molluscum contagiosum)

Coxsackievirus

Herpes simplex virus

Candida

Malassezia (Tinea versicolor and Seborrhoeic dermatitis)

Pediculus humanus and Phthirus pubis (Lice)

Sarcoptes scabiei (Scabies)

Human herpesvirus 6 (Roseola)

Parvovirus B19

Measles virus

Rubella virus

Skin cancer

Alopecia areata

Telogen effluvium

Onychomycosis

Pigmentation skin disorders: Pathology review

Acneiform skin disorders: Pathology review

Papulosquamous and inflammatory skin disorders: Pathology review

Vesiculobullous and desquamating skin disorders: Pathology review

Skin cancer: Pathology review

Radial head subluxation (Nursemaid elbow)

Developmental dysplasia of the hip

Legg-Calve-Perthes disease

Slipped capital femoral epiphysis

Transient synovitis

Osgood-Schlatter disease (traction apophysitis)

Rotator cuff tear

Dislocated shoulder

Winged scapula

Thoracic outlet syndrome

Carpal tunnel syndrome

Ulnar claw

Erb-Duchenne palsy

Klumpke paralysis

Iliotibial band syndrome

Unhappy triad

Anterior cruciate ligament injury

Patellar tendon rupture

Meniscus tear

Patellofemoral pain syndrome

Sprained ankle

Achilles tendon rupture

Spondylolysis

Spondylolisthesis

Degenerative disc disease

Spinal disc herniation

Sciatica

Compartment syndrome

Rhabdomyolysis

Osteogenesis imperfecta

Craniosynostosis

Pectus excavatum

Arthrogryposis

Genu valgum

Genu varum

Pigeon toe

Flat feet

Club foot

Cleidocranial dysplasia

Achondroplasia

Osteomyelitis

Bone tumors

Osteochondroma

Chondrosarcoma

Osteoporosis

Osteomalacia and rickets

Osteopetrosis

Paget disease of bone

Osteosclerosis

Lordosis, kyphosis, and scoliosis

Osteoarthritis

Spondylosis

Spinal stenosis

Rheumatoid arthritis

Juvenile idiopathic arthritis

Gout

Calcium pyrophosphate deposition disease (pseudogout)

Psoriatic arthritis

Ankylosing spondylitis

Reactive arthritis

Spondylitis

Septic arthritis

Bursitis

Baker cyst

Muscular dystrophy

Polymyositis

Dermatomyositis

Inclusion body myopathy

Polymyalgia rheumatica

Fibromyalgia

Rhabdomyosarcoma

Lambert-Eaton myasthenic syndrome

Sjogren syndrome

Mixed connective tissue disease

Raynaud phenomenon

Scleroderma

Back pain: Pathology review

Rheumatoid arthritis and osteoarthritis: Pathology review

Seronegative and septic arthritis: Pathology review

Gout and pseudogout: Pathology review

Systemic lupus erythematosus (SLE): Pathology review

Scleroderma: Pathology review

Sjogren syndrome: Pathology review

Bone disorders: Pathology review

Bone tumors: Pathology review

Myalgias and myositis: Pathology review

Neuromuscular junction disorders: Pathology review

Muscular dystrophies and mitochondrial myopathies: Pathology review

Spina bifida

Chiari malformation

Dandy-Walker malformation

Syringomyelia

Tethered spinal cord syndrome

Aqueductal stenosis

Septo-optic dysplasia

Cerebral palsy

Spinocerebellar ataxia (NORD)

Transient ischemic attack

Ischemic stroke

Intracerebral hemorrhage

Epidural hematoma

Subdural hematoma

Subarachnoid hemorrhage

Saccular aneurysm

Arteriovenous malformation

Broca aphasia

Wernicke aphasia

Wernicke-Korsakoff syndrome

Kluver-Bucy syndrome

Concussion and traumatic brain injury

Shaken baby syndrome

Epilepsy

Febrile seizure

Early infantile epileptic encephalopathy (NORD)

Tension headache

Cluster headache

Migraine

Idiopathic intracranial hypertension

Trigeminal neuralgia

Cavernous sinus thrombosis

Alzheimer disease

Vascular dementia

Frontotemporal dementia

Lewy body dementia

Creutzfeldt-Jakob disease

Normal pressure hydrocephalus

Torticollis

Essential tremor

Restless legs syndrome

Parkinson disease

Huntington disease

Multiple sclerosis

Central pontine myelinolysis

Acute disseminated encephalomyelitis

Transverse myelitis

JC virus (Progressive multifocal leukoencephalopathy)

Adult brain tumors

Pediatric brain tumors

Brain herniation

Brown-Sequard Syndrome

Cauda equina syndrome

Treponema pallidum (Syphilis)

Friedreich ataxia

Neurogenic bladder

Meningitis

Neonatal meningitis

Encephalitis

Brain abscess

Epidural abscess

Sturge-Weber syndrome

Tuberous sclerosis

Neurofibromatosis

von Hippel-Lindau disease

Amyotrophic lateral sclerosis

Spinal muscular atrophy

Poliovirus

Guillain-Barre syndrome

Charcot-Marie-Tooth disease

Bell palsy

Horner syndrome

Congenital neurological disorders: Pathology review

Headaches: Pathology review

Seizures: Pathology review

Cerebral vascular disease: Pathology review

Traumatic brain injury: Pathology review

Spinal cord disorders: Pathology review

Dementia: Pathology review

Central nervous system infections: Pathology review

Movement disorders: Pathology review

Demyelinating disorders: Pathology review

Adult brain tumors: Pathology review

Pediatric brain tumors: Pathology review

Neurocutaneous disorders: Pathology review

Renal agenesis

Horseshoe kidney

Potter sequence

Hyperphosphatemia

Hypophosphatemia

Hypernatremia

Hyponatremia

Hypermagnesemia

Hypomagnesemia

Hyperkalemia

Hypokalemia

Renal tubular acidosis

Minimal change disease

Amyloidosis

Membranous nephropathy

Lupus nephritis

Rapidly progressive glomerulonephritis

IgA nephropathy (NORD)

Alport syndrome

Kidney stones

Hydronephrosis

Acute pyelonephritis

Chronic pyelonephritis

Prerenal azotemia

Renal azotemia

Postrenal azotemia

Renal cortical necrosis

Chronic kidney disease

Multicystic dysplastic kidney

Medullary cystic kidney disease

Medullary sponge kidney

Renal cell carcinoma

Angiomyolipoma

Nephroblastoma (Wilms tumor)

WAGR syndrome

Posterior urethral valves

Hypospadias and epispadias

Vesicoureteral reflux

Bladder exstrophy

Urinary incontinence

Lower urinary tract infection

Transitional cell carcinoma

Non-urothelial bladder cancers

Congenital renal disorders: Pathology review

Renal tubular defects: Pathology review

Renal tubular acidosis: Pathology review

Acid-base disturbances: Pathology review

Electrolyte disturbances: Pathology review

Renal failure: Pathology review

Nephrotic syndromes: Pathology review

Nephritic syndromes: Pathology review

Urinary incontinence: Pathology review

Urinary tract infections: Pathology review

Kidney stones: Pathology review

Renal and urinary tract masses: Pathology review

Klinefelter syndrome

Turner syndrome

Benign prostatic hyperplasia

Prostate cancer

Testicular cancer

Erectile dysfunction

Amenorrhea

Ovarian cyst

Sex cord-gonadal stromal tumor

Surface epithelial-stromal tumor

Germ cell ovarian tumor

Uterine fibroid

Endometriosis

Endometritis

Endometrial hyperplasia

Endometrial cancer

Cervical cancer

Pelvic inflammatory disease

Breast cancer

Preeclampsia & eclampsia

Placenta previa

Placental abruption

Postpartum hemorrhage

Congenital cytomegalovirus (NORD)

Miscarriage

Ectopic pregnancy

Fetal alcohol syndrome

Disorders of sex chromosomes: Pathology review

Prostate disorders and cancer: Pathology review

Testicular tumors: Pathology review

Uterine disorders: Pathology review

Ovarian cysts and tumors: Pathology review

Cervical cancer: Pathology review

Vaginal and vulvar disorders: Pathology review

Benign breast conditions: Pathology review

Breast cancer: Pathology review

Complications during pregnancy: Pathology review

Congenital TORCH infections: Pathology review

Upper respiratory tract infection

Sinusitis

Congenital pulmonary airway malformation

Sudden infant death syndrome

Acute respiratory distress syndrome

Methemoglobinemia

Emphysema

Chronic bronchitis

Cystic fibrosis

Bronchiectasis

Restrictive lung diseases

Sarcoidosis

Idiopathic pulmonary fibrosis

Pneumonia

Lung cancer

Pancoast tumor

Superior vena cava syndrome

Pneumothorax

Pleural effusion

Mesothelioma

Pulmonary embolism

Pulmonary edema

Pulmonary hypertension

Respiratory distress syndrome: Pathology review

Cystic fibrosis: Pathology review

Pneumonia: Pathology review

Tuberculosis: Pathology review

Deep vein thrombosis and pulmonary embolism: Pathology review

Pleural effusion, pneumothorax, hemothorax and atelectasis: Pathology review

Obstructive lung diseases: Pathology review

Restrictive lung diseases: Pathology review

Apnea, hypoventilation and pulmonary hypertension: Pathology review

Lung cancer and mesothelioma: Pathology review

Assessments

Common variable immunodeficiency

Flashcards

0 / 9 complete

USMLE® Step 1 questions

0 / 1 complete

High Yield Notes

10 pages

Flashcards

Common variable immunodeficiency

of complete

Questions

USMLE® Step 1 style questions USMLE

of complete

A 13-year-old girl is brought to her pediatricians office for evaluation of shortness of breath and cough. She has had two episodes of pneumonia over the last two years and an episode of bloody diarrhea six months ago requiring hospitalization. Two years ago, the patient was without any significant health complications. Her only past medical history is asthma. Family history is noncontributory. Her immunizations are up to date. Temperature is 38.7 C° (101.7 F°), pulse is 90/min, respirations are 25/min, and blood pressure is 100/60 mmHg. Height and weight are currently at the 5th percentile for age. Physical examination reveals faint rales over the right lower lung field. No enlarged lymph nodes are palpated on neck examination. Laboratory results are shown.

 
 Laboratory value  Result 
 Complete blood count 
 Hemoglobin  12  g/dL  
 Leukocyte count  10,100 /mm3 
 Platelet count  200,000/mm3 
Immunoglobulins 
IgG  250mg/dL 
 IgA  24 mg/dL 
 IgM  15 mg/dL 
 IgE  undetectable 
 CD4/CD8 ratio  2 (normal, 1-4) 

Chest x-ray reveals a right lower lobe infiltrate. Which of the following is the most likely diagnosis in this patient?  

External References

First Aid

2022

2021

2020

2019

2018

2017

2016

Common variable immunodeficiency (CVID) p. 114

Summary

Common variable immunodeficiency (CVID) is an immune system disorder that impairs your ability to fight infection. It's characterized by low serum levels of all immunoglobulins. People with CVID may present with repeated infections, such as sinus infections, ear infections, pneumonia, and blood infections. They're also at higher risk for other problems, such as autoimmune diseases (diseases where the body mistakenly attacks its tissues), like autoimmune hemolytic anemia, and can also have cancer and gastrointestinal issues. CVID is diagnosed through blood tests through quantitative measurements of the immunoglobulins.

Elsevier

Copyright © 2023 Elsevier, except certain content provided by third parties

Cookies are used by this site.

USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME). COMLEX-USA® is a registered trademark of The National Board of Osteopathic Medical Examiners, Inc. NCLEX-RN® is a registered trademark of the National Council of State Boards of Nursing, Inc. Test names and other trademarks are the property of the respective trademark holders. None of the trademark holders are endorsed by nor affiliated with Osmosis or this website.

RELX