Common variable immunodeficiency
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Common variable immunodeficiency
Immune system
General infections
Sepsis
Neonatal sepsis
Abscesses
Hypersensitivity reactions
Type I hypersensitivity
Food allergy
Anaphylaxis
Asthma
Type II hypersensitivity
Immune thrombocytopenic purpura
Autoimmune hemolytic anemia
Hemolytic disease of the newborn
Goodpasture syndrome
Rheumatic heart disease
Myasthenia gravis
Graves disease
Pemphigus vulgaris
Type III hypersensitivity
Serum sickness
Systemic lupus erythematosus
Poststreptococcal glomerulonephritis
Type IV hypersensitivity
Graft-versus-host disease
Contact dermatitis
Transplants
Transplant rejection
Graft-versus-host disease
Cytomegalovirus infection after transplant (NORD)
Post-transplant lymphoproliferative disorders (NORD)
Immunodeficiences
X-linked agammaglobulinemia
Selective immunoglobulin A deficiency
Common variable immunodeficiency
IgG subclass deficiency
Hyperimmunoglobulin E syndrome
Isolated primary immunoglobulin M deficiency
Thymic aplasia
DiGeorge syndrome
Severe combined immunodeficiency
Adenosine deaminase deficiency
Ataxia-telangiectasia
Hyper IgM syndrome
Wiskott-Aldrich syndrome
Leukocyte adhesion deficiency
Chediak-Higashi syndrome
Chronic granulomatous disease
Complement deficiency
Hereditary angioedema
Asplenia
Immune system organ disorders
Thymoma
Ruptured spleen
Immune system pathology review
Blood transfusion reactions and transplant rejection: Pathology review
Immunodeficiencies: T-cell and B-cell disorders: Pathology review
Immunodeficiencies: Combined T-cell and B-cell disorders: Pathology review
Immunodeficiencies: Phagocyte and complement dysfunction: Pathology review
Assessments
Common variable immunodeficiency
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USMLE® Step 1 questions
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High Yield Notes
10 pages
Flashcards
Common variable immunodeficiency
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Questions
USMLE® Step 1 style questions USMLE
of complete
| Laboratory value | Result |
| Complete blood count | |
| Hemoglobin | 12 g/dL |
| Leukocyte count | 10,100 /mm3 |
| Platelet count | 200,000/mm3 |
| Immunoglobulins | |
| IgG | 250mg/dL |
| IgA | 24 mg/dL |
| IgM | 15 mg/dL |
| IgE | undetectable |
| CD4/CD8 ratio | 2 (normal, 1-4) |
Chest x-ray reveals a right lower lobe infiltrate. Which of the following is the most likely diagnosis in this patient?
Memory Anchors and Partner Content
External References
First Aid
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Common variable immunodeficiency (CVID) p. 114
External Links
Summary
Common variable immunodeficiency (CVID) is an immune system disorder that impairs your ability to fight infection. It's characterized by low serum levels of all immunoglobulins. People with CVID may present with repeated infections, such as sinus infections, ear infections, pneumonia, and blood infections. They're also at higher risk for other problems, such as autoimmune diseases (diseases where the body mistakenly attacks its tissues), like autoimmune hemolytic anemia, and can also have cancer and gastrointestinal issues. CVID is diagnosed through blood tests through quantitative measurements of the immunoglobulins.
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