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Congenital adrenal hyperplasia



Endocrine system


Adrenal gland disorders
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Congenital adrenal hyperplasia


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High Yield Notes
3 pages

Congenital adrenal hyperplasia

11 flashcards

USMLE® Step 1 style questions USMLE

5 questions

A 15-year-old girl presents to her pediatrician for a routine check up. She is doing well in school, but her friends have been making fun of her since she has not “hit puberty yet.” Past medical history is noncontributory, and she does not use any illicit substances. She is currently not taking any medications. Temperature is 37.0°C (98.6°F), pulse is 80/min, respirations are 16/min, blood pressure is 156/71 mmHg, and oxygen saturation is 98% on room air. Physical examination is notable for tanner stage I of development. Which of the following laboratory findings is most likely to be observed in this patient?

External References

With congenital adrenal hyperplasia, congenital means present from birth, adrenals refer to the two adrenal glands that sit above the kidney, and hyperplasia refers to increased cell proliferation which leads to tissue growth.

So congenital adrenal hyperplasia is a disease where there are enlarged adrenal glands that are present at birth, and the reason for the adrenal enlargement is that there’s a deficiency in an enzyme involved with steroid production.

Now, each adrenal gland one has an inner layer called the medulla and an outer layer called the cortex which is subdivided into three more layers, the zona glomerulosa, zona fasciculata, and the zona reticularis.

The outermost layer is the zona glomerulosa, and it’s full of cells that make the hormone aldosterone.

The first step in aldosterone production is when an enzyme called cholesterol desmolase turns cholesterol into pregnenolone.

Pregnenolone is the precursor to all of the adrenal cortex hormones, sometimes called the steroid hormones.

Next, pregnenolone is turned into progesterone by the enzyme 3 beta-hydroxysteroid dehydrogenase.

Then, progesterone is turned into 11 deoxycorticosterone by the enzyme 21 hydroxylase.

11 deoxycorticosterone then gets turned into corticosterone by the enzyme 11 beta-hydroxylase.

And finally, corticosterone is turned into aldosterone by the enzyme aldosterone synthase.

Whew! That’s like going through the washing machine twice.

So the final result is aldosterone which is part of a hormone family called the renin-angiotensin-aldosterone system.

Aldosterone signals the kidney to reabsorb more Na+ into the blood and excrete more potassium.

When Na+ is reabsorbed, water also moves into the blood, which increases blood volume and blood pressure.

The middle layer of the adrenal cortex is the zona fasciculata, and the cells there make the hormone cortisol.

This process starts when pregnenolone and progesterone move into the zona fasciculata.

The enzyme 17 alpha -hydroxylase turns pregnenolone into 17 hydroxypregnenolone and turns progesterone into 17 hydroxyprogesterone.

17 hydroxypregnenolone is then turned into 17 hydroxyprogesterone by the enzyme 3 beta-hydroxysteroid dehydrogenase.

Then, all of the 17 hydroxyprogesterone is turned into 11 deoxycortisol by the enzyme 21 hydroxylase.

11 deoxycortisol is finally turned into cortisol by the enzyme 11 beta-hydroxylase.

Cortisol is needed in times of emotional and physical stress like arguing with a friend or fleeing from a pack of raccoons.

In those situations, the hypothalamus—which is an almond-size structure in the brain, releases corticotropin-releasing hormone which acts on the pituitary gland, the pea-sized structure sitting just underneath the hypothalamus.

In response, the pituitary gland sends out adrenocorticotropic hormone, or ACTH, which travels through the blood to the zona fasciculata of the adrenal glands and signals cells there to release cortisol.

One of cortisol’s main jobs is to increase blood glucose levels by promoting gluconeogenesis in the liver.

This is the formation of glucose from noncarbohydrate sources, like amino acids or free fatty acids.

Cortisol also gets the muscles to break down proteins into amino acids and gets adipose tissues to break down fats into free fatty acids, both of which provide the liver with more raw materials to work with.

The increase in glucose lets the body respond appropriately to those raccoons, or other stressors.

Finally, there’s the innermost layer of the adrenal cortex which is the zona reticularis, and cells there make a group of sex hormones called androgens.

This process starts when 17 hydroxypregnenolone and 17 hydroxyprogesterone from the zona fasciculata move into the zona reticularis.

The enzyme 17, 20 lyase turns 17 hydroxypregnenolone into dehydroepiandrosterone and turns 17 hydroxyprogesterone into androstenedione.

Dehydroepiandrosterone can also be turned into androstenedione by the enzyme 3 beta-hydroxysteroid dehydrogenase.

Then, androstenedione is turned into testosterone by the enzyme 17 beta hydroxysteroid dehydrogenase.

Alternatively you can also get testosterone by converting dehydroepiandrosterone to androstendiol first with the same enzyme, then using 3 beta hydroxysteroid dehydrogenase to get testosterone.

The adrenal glands are involved in testosterone production in both men and women, but the amount that the adrenals contribute is pretty small in men compared to the testes.

In men testosterone is responsible for the development of male reproductive organs and secondary sex characteristics like voice changes and facial, underarm, and pubic hair.

Since women do not have testes, they have relatively low levels of testosterone, and it’s just enough to influence secondary sex characteristics like underarm and pubic hair.

Congenital adrenal hyperplasia can be caused by a number of enzyme deficiencies in the adrenocortical steroid pathway.

These enzyme deficiencies result in low levels of multiple adrenocortical steroids, with cortisol always being one of them.

Low level of cortisol triggers the pituitary to release more ACTH which stimulates the cells in the adrenal gland to continually proliferate.

This results in the enlargement, or hyperplasia, of the adrenal gland.

The most common enzyme deficiency is 21 hydroxylase deficiency which is found in both the zona glomerulosa and the zona fasciculata.


Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders that affect the glandular cells in the adrenal cortex. This produces abnormal amounts of certain hormones, including cortisol, aldosterone, and androgen. These hormones are responsible for many essential functions in the body, including stress response, blood pressure, and kidney function.

There are several forms of CAH, each caused by a specific gene mutation. The most common form is called 21-hydroxylase deficiency, caused by a mutation in the CYP21A2 gene. 21-hydroxylase deficiency presents with masculinization in women and salt wasting, and hypoglycemia.

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