Assessment of Crigler-Najjar syndrome: Video, Anatomy & Definition | Osmosis

Question

A 20-hour-old female infant is reviewed on the ward because of neonatal jaundice. She was born at term following an uncomplicated pregnancy. She has passed meconium. Physical examination shows she is alert, well perfused, feeding normally, and afebrile. She is jaundiced over face, trunk, and limbs, and has no organomegaly. Laboratory studies show an elevated unconjugated bilirubin of 426 μmol/L (25mg/dL) (reference range 2–14 μmol/L [0.1-0.8 mg/dL]), normal liver function tests, and no evidence of hemolysis. Which of the following diagnoses is the most likely cause of jaundice in this newborn?

Accepted Answer

Crigler&#8211;Najjar syndrome

Answer

Gilbert's syndrome

Answer

Physiological jaundice

Answer

Sepsis

Answer

Rhesus incompatability

Questions or feedback?

Crigler-Najjar syndrome

Pathology

Gastrointestinal system