00:00 / 00:00
Alcohol-induced liver disease
Alpha 1-antitrypsin deficiency
Benign liver tumors
Cholestatic liver disease
Non-alcoholic fatty liver disease
Primary biliary cirrhosis
Primary sclerosing cholangitis
Pancreatic neuroendocrine neoplasms
Familial adenomatous polyposis
Juvenile polyposis syndrome
Small bowel ischemia and infarction
Protein losing enteropathy
Short bowel syndrome (NORD)
Small bowel bacterial overgrowth syndrome
Diverticulosis and diverticulitis
Irritable bowel syndrome
Cleft lip and palate
Congenital diaphragmatic hernia
Diffuse esophageal spasm
Eosinophilic esophagitis (NORD)
Gastroesophageal reflux disease (GERD)
Cyclic vomiting syndrome
Gastric dumping syndrome
Dental caries disease
Gingivitis and periodontitis
Temporomandibular joint dysfunction
Appendicitis: Pathology review
Cirrhosis: Pathology review
Colorectal polyps and cancer: Pathology review
Congenital gastrointestinal disorders: Pathology review
Diverticular disease: Pathology review
Esophageal disorders: Pathology review
Gallbladder disorders: Pathology review
Gastrointestinal bleeding: Pathology review
GERD, peptic ulcers, gastritis, and stomach cancer: Pathology review
Inflammatory bowel disease: Pathology review
Jaundice: Pathology review
Malabsorption syndromes: Pathology review
Neuroendocrine tumors of the gastrointestinal system: Pathology review
Pancreatitis: Pathology review
Viral hepatitis: Pathology review
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0 / 8 complete
Crohn's Disease Assessment
Crohn's Disease Characteristics
Crohn's Symptoms and Associations
Crohn's Disease & Ulcerative Colitis
for Crohn disease p. 389
Crohn disease p. 389
azathioprine p. 118
BNaN deficiency p. 426
cholelithiasis and p. 403
as granulomatous disease p. NaN
lesions in p. 734
natalizumab p. 120
spondyloarthritis and p. 475
sulfasalazine for p. 407
vitamin BNaN deficiency p. 67
Crohn disease association p. 389
Crohn’s disease, now more frequently referred to as Crohn disease, is an inflammatory bowel disease that, well, causes inflammation of the bowel.
Unlike its cousin, ulcerative colitis, which only affects the large intestine, Crohn disease causes inflammation and tissue destruction anywhere along the gastrointestinal tract, from the mouth to the anus.
Although ulcerative colitis is classified and treated as an autoimmune disease, Crohn disease isn’t technically classified as an autoimmune disease, but rather an immune-related disorder...what does that mean exactly?
Well, with “auto” immune, we think that your own cells and proteins trigger the immune system to start attacking itself.
In Crohn disease, the immune system is thought to be triggered by some foreign pathogen in the gastrointestinal tract.
Several pathogens have been implicated, like Mycobacterium paratuberculosis as well Pseudomona and Listeria species.
So the immune system’s reacting to foreign pathogens...isn’t that what it’s supposed to be doing? Well, yes and no; yes because it’s targeting a foreign invader, no because the inflammatory response is large and uncontrolled and leads to destruction of the cells in the gastrointestinal tract.
So what’s thought to happen is one of these pathogens activates the immune system by antigen presentation, meaning one of the gastrointestinal cells is like “here, I think this is an infectious molecule”, and that’s fine, because it is.
At that point T helper cells, or Th1 cells swoop in and release cytokines—which are cell signaling molecules—like interferon-gamma, and tumor necrosis factor alpha, which further stimulate the inflammatory response.
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