Cyanide poisoning
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Cyanide poisoning
Respiratory system
Apnea and hypoventilation
Lower respiratory tract disorders
Acute respiratory distress syndrome
Cyanide poisoning
Decompression sickness
Methemoglobinemia
Respiratory distress syndrome: Pathology review
Apnea of prematurity
Meconium aspiration syndrome
Neonatal respiratory distress syndrome
Sudden infant death syndrome
Transient tachypnea of the newborn
Congenital pulmonary airway malformation
Pulmonary hypoplasia
Tracheoesophageal fistula
Bacterial tracheitis
Croup
Pneumonia
Pneumonia: Pathology review
Tuberculosis: Pathology review
Alpha 1-antitrypsin deficiency
Asthma
Bronchiectasis
Chronic bronchitis
Cystic fibrosis
Cystic fibrosis: Pathology review
Emphysema
Obstructive lung diseases: Pathology review
Idiopathic pulmonary fibrosis
Restrictive lung diseases
Restrictive lung diseases: Pathology review
Sarcoidosis
Primary ciliary dyskinesia
Lung cancer
Lung cancer and mesothelioma: Pathology review
Pancoast tumor
Superior vena cava syndrome
Pleura and pleural space disorders
Pulmonary vascular disorders
Assessments
Flashcards
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USMLE® Step 1 questions
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High Yield Notes
15 pages
Flashcards
Cyanide poisoning
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Questions
USMLE® Step 1 style questions USMLE
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A 25-year-old woman is brought to the emergency department after being found unconscious near the doorway of a smoke-filled house. Temperature is 37.3°C (99.1°F), pulse is 120/minute, respirations are 20/min, and blood pressure is 110/65 mm Hg. Physical examination shows generalized flushing of the skin as well as black soot near the nares and mouth. There is no evidence of any burns or trauma. Capillary refill time is 5 seconds. Supplemental oxygen is administered. Laboratory results are shown below. Hydroxocobalamin is provided for medical management. Which of the following best describes the mechanism of action of this medication?
Summary
Cyanide poisoning is a type of chemical poisoning that occurs when cyanide ions are introduced into the body. Cyanide ions disrupt cellular respiration at the mitochondrial level, by inhibiting an enzyme called cytochrome C oxidase. This can lead to asphyxiation as the body is no longer able to use oxygen, and it can also cause damage to the heart, liver, and other organs. Symptoms of cyanide poisoning may include headache, seizures, confusion, nausea, cardiac arrest, and death.