Cystinuria (NORD)

00:00 / 00:00



Cystinuria (NORD)



Cystinuria (NORD)


0 / 10 complete

USMLE® Step 1 questions

0 / 1 complete

High Yield Notes

7 pages


Cystinuria (NORD)

of complete


USMLE® Step 1 style questions USMLE

of complete

A 13-year-old girl comes to the emergency room with abdominal pain. The pain was sudden in onset and localized to the right lower abdomen.  She has had blood in her urine and 2 episodes of vomiting since this morning. She is not sexually active and does not smoke, use illicit drugs or consume alcohol. Temperature is 37.0°C (98.6°F), pulse is 96/min, respirations are 20/min, and blood pressure is 125/85 mmHg. Physical examination reveals nodulocystic acne. Abdominal examination is notable for tenderness in the right flank. Routine urinalysis is positive for blood and 5-10 erythrocytes/hpf. A noncontrast CT detects a staghorn calculus in the right proximal ureter with mild dilation of the pelvic calyxes. Urine cyanide nitroprusside test is found to be positive. Which of the following crystals are likely to be found on urinalysis?

External References

First Aid









cystinuria p. 83

Cystinuria p. 83


in cystinuria p. 83


cystinuria p. 83


Cystinuria is an inherited metabolic disorder named because of high levels of the amino acid cystine found in urine. The chemically similar amino acids arginine, lysine, and ornithine are also found in high levels.

The kidneys are two bean-shaped organs in the body that filter out waste products and excess water from blood to produce urine. Typically, amino acids are recovered from urine and reabsorbed into the blood by the kidneys. But in cystinuria, impaired reabsorption of cystine, arginine, lysine, and ornithine leads to excessive amounts in urine. At high concentration, cystine clumps together to form crystals and stones, also called calculi. These can be found along the urinary tract, including the kidneys, ureters, and urinary bladder.

While high levels of cystine, arginine, lysine, and ornithine in the urine are characteristics of the disorder, the main signs and symptoms are caused only by the cystine crystals and stones. As they stick together and grow larger, they form lemon-yellow stones. Stones are jagged and can cause sharp pains in the sides and lower back that can radiate to the lower abdomen and groin when they cause obstruction of the ureters. The pain can come in waves and may be present when urinating. Stones can also cause injury to tissues in the urinary tract, which can lead to blood in the urine. Frequent recurrences may ultimately lead to lasting kidney damage. Depending on their size, stones may obstruct the urinary tract and slow or stop the flow of urine. This can lead to additional complications, like urinary tract infections. Some individuals won’t form stones, but others typically begin having these symptoms between 10 and 30 years old.

With a normal pH of urine, high levels of arginine, lysine, and ornithine can be excreted in massive amounts without additional complications. But high levels of cystine are not as soluble and need urine with a higher pH to completely dissolve. Undissolved cystine clumps together to form crystals and stones. And clumping is more likely when urine volume is low as cystine becomes more concentrated.

Cystinuria is an inherited disorder caused by changes, or mutations, in either the SLC3A1 or SLC7A9 gene. These mutations impair the normal reabsorption of cystine, arginine, lysine, and ornithine. Cystinuria is an autosomal recessive disorder, which means an individual needs to inherit a mutated copy of the SLC3A1 or SLC7A9 gene from each parent to be affected. If an individual inherits one mutated and one normal copy, they are considered carriers for the disorder. Carriers usually have minimal to no signs and symptoms of cystinuria. A few people seem to make stones with only one abnormal SLC7A9 gene.


Cystinuria is an inherited metabolic disorder that causes the body to accumulate large amounts of cysteine. Too much cysteine in urine can precipitate into crystals and renal stones, leading to associated symptoms like renal colic (intense pain in the lower back flanks and iliac fossae), hematuria, urinary tract obstruction which increases the risk of infections, and possible damage to the kidneys due to obstruction of the urinary tract.


Copyright © 2023 Elsevier, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

Cookies are used by this site.

USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME). COMLEX-USA® is a registered trademark of The National Board of Osteopathic Medical Examiners, Inc. NCLEX-RN® is a registered trademark of the National Council of State Boards of Nursing, Inc. Test names and other trademarks are the property of the respective trademark holders. None of the trademark holders are endorsed by nor affiliated with Osmosis or this website.