Cytomegalovirus

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Summary of Cytomegalovirus

The cytomegalovirus, also known as human herpesvirus 5, is an enveloped, double stranded, linear DNA virus that causes infectious mononucleosis with a negative Monospot test. It characteristically causes esophagitis, retinitis, and atypical pneumonia in immunocompromised patients, with "owl eye" inclusion bodies in infected cells. It can also lie latent in mononuclear cells, and become reactivated in times of immunosuppression or severe systemic disease. It is spread through saliva, urine, sexual contact, or transplanted organs. Treatment is with ganciclovir, or with foscarnet/cidofovir if ganciclovir resistance.

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Cytomegalovirus

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Cytomegalovirus

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A 17-year-old girl presents for evaluation of sore throat and fatigue. The patient's symptoms have been ongoing for the past week. According to the patient, “I think I picked up a bug from my partner, he had a similar illness about three-weeks ago.” The patient is otherwise healthy and does not take any medications. Temperature is 38.2°C (100.8°F), pulse is 80/min, respirations are 14/min, and blood pressure is 125/71 mmHg. Physical examination demonstrates posterior auricular and posterior cervical lymphadenopathy, as well as bilateral tonsillar swelling. A heterophile antibody screen is negative. Which of the following is the most likely pathogen responsible for this patient’s symptoms?

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