Summary of Cytomegalovirus
The cytomegalovirus, also known as human herpesvirus 5, is an enveloped, double stranded, linear DNA virus that causes infectious mononucleosis with a negative Monospot test. It characteristically causes esophagitis, retinitis, and atypical pneumonia in immunocompromised patients, with "owl eye" inclusion bodies in infected cells. It can also lie latent in mononuclear cells, and become reactivated in times of immunosuppression or severe systemic disease. It is spread through saliva, urine, sexual contact, or transplanted organs. Treatment is with ganciclovir, or with foscarnet/cidofovir if ganciclovir resistance.