Assessment of Diabetes insipidus and SIADH: Pathology review: Video | Osmosis

Question

A 30 year-old woman comes to her primary care physician because of muscle cramps, nausea, and fatigue. The patient endorses a history of depression and seizure disorder, both of which are currently managed with medications. Family history is notable for Addison disease in her maternal uncle. Temperature is 36.9°C (98.4°F), pulse is 75/min, respirations are 14/min and blood pressure is 115/80 mmHg. Cardiac, pulmonary, and abdominal examinations are noncontributory. Additional laboratory results are as follows:

Laboratory value	Result
Sodium	122 mEq/L
Potassium	3.7 mEq/L
Creatinine	0.9 mg/dL
Glucose	102 mg/dL
Serum osmolality	240 mOsm/kg
Urine osmolality	445 mOsm/kg

Which of the following is the most likely explanation of the patient’s symptoms?

Accepted Answer

Syndrome of inappropriate antidiuretic hormone secretion (SIADH)

Answer

Diabetes insipidus

Answer

Adrenal insufficiency

Answer

Primary polydipsia

Answer

Surreptitious diuretic use

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Diabetes insipidus and SIADH: Pathology review

Pathology

Endocrine system