Skip to content

Dubin-Johnson syndrome

Summary of Dubin-Johnson syndrome
Dubin–Johnson syndrome is a rare, autosomal recessive, benign disorder that causes an isolated increase of conjugated bilirubin in the serum. Classically, the condition causes a black liver due to the deposition of a pigment similar to melanin. This condition is associated with a defect in the ability of hepatocytes to secrete conjugated bilirubin into the bile, and is similar to Rotor syndrome. It is usually asymptomatic, but may be diagnosed in early infancy based on laboratory tests. No treatment is usually needed.

Videos

Notes

Pathology

Gastrointestinal system

Peritoneum and peritoneal cavity disorders
Upper gastrointestinal tract disorders
Lower gastrointestinal tract disorders
Liver, gallbladder and pancreas disorders
Gastrointestinal system pathology review

Assessments
Dubin-Johnson syndrome

Flashcards

0 / 5 complete

Questions

0 / 2 complete
High Yield Notes
6 pages
Flashcards

Dubin-Johnson syndrome

5 flashcards
Preview

Dubin-Johnson syndrome presents with (conjugated/unconjugated) hyperbilirubinemia.

Questions

USMLE® Step 1 style questions USMLE

2 questions

USMLE® Step 2 style questions USMLE

1 questions
Preview

A 5-month-old infant comes for an office visit. Laboratory results show congenital hyperbilirubinemia. AST and ALT concentrations are normal, and his coproporphyrin I to coproporphyrin III ratio is greatly increased. A liver biopsy shows a dark green macroscopic specimen. Which of the following is the most likely diagnosis? 

External References