Dubin-Johnson syndrome
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Dubin-Johnson syndrome
GI
GI
Anatomy of the pharynx and esophagus
Anatomy of the oral cavity
Anatomy of the salivary glands
Anatomy of the tongue
Anatomy of the anterolateral abdominal wall
Anatomy of the gastrointestinal organs of the pelvis and perineum
Anatomy of the muscles and nerves of the posterior abdominal wall
Anatomy of the peritoneum and peritoneal cavity
Anatomy of the inguinal region
Anatomy clinical correlates: Anterior and posterior abdominal wall
Development of the digestive system and body cavities
Development of the gastrointestinal system
Esophagus histology
Gastrointestinal system anatomy and physiology
Enteric nervous system
Esophageal motility
Gastric motility
Chewing and swallowing
Esophageal web
Achalasia
Zenker diverticulum
Esophageal cancer
Gastroschisis
Esophageal disorders: Pathology review
Esophageal disorders: Clinical
Anatomy of the abdominal viscera: Large intestine
Anatomy of the abdominal viscera: Innervation of the abdominal viscera
Anatomy of the abdominal viscera: Small intestine
Stomach histology
Colon histology
Small intestine histology
Gastrointestinal hormones
Fats and lipids
Pancreatic secretion
Intestinal fluid balance
Proteins
Carbohydrates and sugars
Peritonitis
Pyloric stenosis
Gastritis
Peptic ulcer
Cyclic vomiting syndrome
Gastric cancer
Gastroenteritis
Gastroparesis
Omphalocele
Intestinal atresia
Intestinal malrotation
Hirschsprung disease
Meckel diverticulum
Imperforate anus
Intussusception
Celiac disease
Lactose intolerance
Whipple's disease
Crohn disease
Ulcerative colitis
Microscopic colitis
Bowel obstruction
Volvulus
Abdominal hernias
Inguinal hernia
Femoral hernia
Ischemic colitis
Small bowel ischemia and infarction
Irritable bowel syndrome
Diverticulosis and diverticulitis
Appendicitis
Anal fissure
Hemorrhoid
Anal fistula
Acute pancreatitis
Chronic pancreatitis
Zollinger-Ellison syndrome
Inflammatory bowel disease: Pathology review
Diverticular disease: Pathology review
Gastrointestinal bleeding: Pathology review
Pancreatitis: Pathology review
Congenital gastrointestinal disorders: Pathology review
GERD, peptic ulcers, gastritis, and stomach cancer: Pathology review
Malabsorption syndromes: Pathology review
Appendicitis: Pathology review
Laxatives and cathartics
Acid reducing medications
Antidiarrheals
Clostridium difficile (Pseudomembranous colitis)
Escherichia coli
Vibrio cholerae (Cholera)
Campylobacter jejuni
Helicobacter pylori
Norovirus
Rotavirus
Entamoeba histolytica (Amebiasis)
Giardia lamblia
Cryptosporidium
Ancylostoma duodenale and Necator americanus
Enterobius vermicularis (Pinworm)
Trichinella spiralis
Trichuris trichiura (Whipworm)
Hunger and satiety
Insulin
Somatostatin
Glucagon
Hydration
Essential fructosuria
Galactosemia
Hereditary fructose intolerance
Anatomy of the abdominal viscera: Liver, biliary ducts and gallbladder
Anatomy of the abdominal viscera: Pancreas and spleen
Anatomy of the abdominal viscera: Blood supply of the foregut, midgut and hindgut
Anatomy clinical correlates: Other abdominal organs
Anatomy clinical correlates: Viscera of the gastrointestinal tract
Gallbladder histology
Liver histology
Pancreas histology
Liver anatomy and physiology
Bile secretion and enterohepatic circulation
Familial adenomatous polyposis
Colorectal polyps
Colorectal cancer
Juvenile polyposis syndrome
Peutz-Jeghers syndrome
Carcinoid syndrome
Jaundice
Cirrhosis
Portal hypertension
Wilson disease
Non-alcoholic fatty liver disease
Budd-Chiari syndrome
Cholestatic liver disease
Hepatocellular adenoma
Alcohol-induced liver disease
Autoimmune hepatitis
Primary sclerosing cholangitis
Benign liver tumors
Hepatocellular carcinoma
Reye syndrome
Hepatitis
Gallstones
Acute cholecystitis
Chronic cholecystitis
Pancreatic cancer
Pancreatic pseudocyst
Pancreatic neuroendocrine neoplasms
Jaundice: Pathology review
Cirrhosis: Pathology review
Viral hepatitis: Pathology review
Gallbladder disorders: Pathology review
Colorectal polyps and cancer: Pathology review
Hypercholesterolemia: Clinical
Dyslipidemias: Pathology review
Hepatitis C virus
Familial hypercholesterolemia
Hyperlipidemia
Lysosomal storage disorders: Pathology review
Cholesterol metabolism
Gaucher disease (NORD)
Krabbe disease
Niemann-Pick disease types A and B (NORD)
Niemann-Pick disease type C
Tay-Sachs disease (NORD)
Fabry disease (NORD)
Metachromatic leukodystrophy (NORD)
Leukodystrophy
Abetalipoproteinemia
Hypertriglyceridemia
Disorders of fatty acid metabolism: Pathology review
Crigler-Najjar syndrome
Gilbert's syndrome
Rotor syndrome
Dubin-Johnson syndrome
Biliary atresia
Hepatic encephalopathy
Primary biliary cirrhosis
Hemochromatosis
Biliary colic
Ascending cholangitis
Gallstone ileus
Cholangiocarcinoma
Gallbladder cancer
Heme synthesis disorders: Pathology review
Cirrhosis: Clinical
Appendicitis: Clinical
Abdominal pain: Clinical
Gastrointestinal bleeding: Clinical
Peptic ulcers and stomach cancer: Clinical
Inflammatory bowel disease: Clinical
Diverticular disease: Clinical
Gallbladder disorders: Clinical
Pancreatitis: Clinical
Hernias: Clinical
Bowel obstruction: Clinical
Abdominal trauma: Clinical
Diarrhea: Clinical
Esophagitis: Clinical
Anal conditions: Clinical
Malabsorption: Clinical
Gastroparesis: Clinical
Gastroesophageal reflux disease (GERD): Clinical
Jaundice: Clinical
Viral hepatitis: Clinical
Transplant rejection
Graft-versus-host disease
Folate (Vitamin B9) deficiency
Vitamin D
Vitamin C deficiency
Vitamin D deficiency
Vitamin B12 deficiency
Niacin (Vitamin B3) deficiency
Vitamin K deficiency
Fat-soluble vitamin deficiency and toxicity: Pathology review
Water-soluble vitamin deficiency and toxicity: B1-B7: Pathology review
Vitamins and minerals
Intestinal adhesions
Assessments
Flashcards
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USMLE® Step 1 questions
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High Yield Notes
6 pages
Flashcards
Dubin-Johnson syndrome
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Questions
USMLE® Step 1 style questions USMLE
0 of 3 complete
A 51-year-old man comes to his outpatient provider for evaluation of epigastric abdominal pain and unintentional weight loss. The symptoms began 6 months ago and the patient has lost 4 kg (8.8 lb) during this time period. Review of systems is notable for fatigue and pruritus over this same time period. Past medical history is notable for alcohol use disorder. The patient has a 35-pack-year smoking history. In the office, his temperature is 37.6°C (99.7°F), blood pressure is 125/77 mmHg, and pulse is 72/min. Physical examination shows an enlarged, palpable, but non-tender, gallbladder. Examination of the patient’s eyes reveals the following finding:
Reproduced from: Wikimedia Commons
Cardiac and pulmonary exams are noncontributory. Serum carbohydrate antigen 19-9 levels are elevated. Which of the following laboratory findings would most likely be present in this patient?
Reproduced from: Wikimedia Commons
Cardiac and pulmonary exams are noncontributory. Serum carbohydrate antigen 19-9 levels are elevated. Which of the following laboratory findings would most likely be present in this patient?
External References
First Aid
2024
2023
2022
2021
Dubin-Johnson syndrome p. 400, 400
Summary
Dubin-Johnson syndrome is a rare autosomal genetic disorder characterized by some elevation of conjugated bilirubin but no other signs of injury to the hepatocytes. It's also associated with a black liver due to the deposition of a pigment similar to melanin. Dubin-Johnson syndrome is generally asymptomatic, and no treatment is usually needed.