Content Reviewers:Yifan Xiao, MD
Antifungals work either through fungistatic action, meaning that they inhibit fungal growth, or through fungicidal action, meaning they kill the fungi.
Now, most fungi have a protective cell wall made of different carbohydrate molecules.
Some fungal species have beta glucans which are polysaccharide polymers that are cross linked with other carbohydrate molecules to make a strong fungal cell wall.
Beta glucans are produced by an enzyme on the cell membrane called beta-1,3-D-glucan synthase.
This enzyme is not found in human cells which makes it a good target for antifungal medications.
Now, echinocandins are a type of medication that noncompetitively bind to and inhibit beta-1,3-D-glucan synthase.
This weakens the cell wall and prevents it from being repaired.
The cell wall gradually deforms more and more until it ruptures, causing the cell to die.
Echinocandins are only available via IV since they are not well absorbed through the GI tract.
They are only effective against fungal species that have beta-1,3-D-glucan synthase, but it’s extremely rare for these organisms to have resistance to these medications.
Echinocandins are used to treat mucocutaneous candidiasis, which affect the skin, nails, and oral mucosa, or disseminated candidiasis, where the infection spreads to multiple organ systems through the blood, causing endocarditis, endophthalmitis, and osteomyelitis.
This is only seen in people with a compromised immune system like those with an HIV infection, or patients undergoing chemotherapy.
In immunocompromised people, the infection can spread into the blood, causing invasive aspergillosis which can very quickly become fatal.
- "Katzung & Trevor's Pharmacology Examination and Board Review,12th Edition" McGraw-Hill Education / Medical (2018)
- "Rang and Dale's Pharmacology" Elsevier (2019)
- "Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th Edition" McGraw-Hill Education / Medical (2017)
- "Echinocandins--new antifungal agents" Rev Med Chir Soc Med Nat Iasi (2014)
- "Echinocandins in antifungal pharmacotherapy" Journal of Pharmacy and Pharmacology (2017)
- "Clinical hepatotoxicity associated with antifungal agents" Expert Opinion on Drug Safety (2016)