AssessmentsEssential thrombocythemia (NORD)
Essential thrombocythemia (NORD)
USMLE® Step 1 style questions USMLE
A 51-year-old female comes to the emergency department because of shortness of breath that began an hour ago. Three days ago, the patient returned from a business trip in Europe. Past medical history is notable for hypertension. The patient has been taking oral estrogen for management of menopausal symptoms. Her temperature is 37.8°C (100.0°F), blood pressure is 148/89, pulse is 130/min, and respiratory rate is 27/min. Oxygen saturation is 86% on room air. Physical examination reveals splenomegaly. Coagulation studies show a prothrombin time (PT) of 12 seconds and partial thromboplastin time (PTT) of 34 seconds. A peripheral blood smear shows the following:
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Computed tomography subsequently confirms the presence of a pulmonary embolus. Which of the following best explains the pathophysiology of this patient presentation?
Content Reviewers:Rishi Desai, MD, MPH
Now, the vast majority of bone marrow is made of hematopoietic cells which are the early progenitor cells that can differentiate into other cell types.
In the case of platelets, progenitor cells differentiate into megakaryocytes, whi