Assessment of Essential thrombocythemia (NORD): Video & Anatomy | Osmosis

Question

A 68-year-old male comes to his provider’s office for evaluation of fatigue, weakness, and 8 kg (17.6 lb) unintentional weight loss over the past 2 months. Moreover, the patient reports feeling bloated after eating small quantities of food during this same time period. His past medical history is notable for hypertension, and the patient is currently taking hydrochlorothiazide. Physical exam reveals oral mucosal pallor. Cardiac and pulmonary exams are non-contributory. Abdominal exam reveals hepatosplenomegaly. Laboratory testing results are as follows:

Laboratory value Result
Hemoglobin 9.5 g/dL
Hematocrit 28.5%
Leukocytes 2,700/mm3
Platelets 100,000/mm3

Biopsy of the bone marrow biopsy shows increased fibrosis and reduced cell count. Polymerase chain reaction testing reveals a mutation in a gene encoding for a non-receptor tyrosine kinase. Which of the following diseases is also caused by an identical mutation?

Accepted Answer

Polycythemia vera&#160;

Answer

Fanconi anemia

Answer

Chronic myeloid leukemia

Answer

Follicular lymphoma

Answer

Acute myeloid leukemia

Questions or feedback?

Essential thrombocythemia (NORD)

Pathology

Hematological system