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Amino acid metabolism
Nitrogen and urea cycle
Citric acid cycle
Electron transport chain and oxidative phosphorylation
Pentose phosphate pathway
Physiological changes during exercise
Fatty acid oxidation
Fatty acid synthesis
Ketone body metabolism
Maple syrup urine disease
Ornithine transcarbamylase deficiency
Glucose-6-phosphate dehydrogenase (G6PD) deficiency
Hereditary fructose intolerance
Pyruvate dehydrogenase deficiency
Glycogen storage disease type I
Glycogen storage disease type II (NORD)
Glycogen storage disease type III
Glycogen storage disease type IV
Glycogen storage disease type V
Mucopolysaccharide storage disease type 1 (Hurler syndrome) (NORD)
Mucopolysaccharide storage disease type 2 (Hunter syndrome) (NORD)
Fabry disease (NORD)
Gaucher disease (NORD)
Metachromatic leukodystrophy (NORD)
Niemann-Pick disease type C
Niemann-Pick disease types A and B (NORD)
Tay-Sachs disease (NORD)
Disorders of amino acid metabolism: Pathology review
Disorders of carbohydrate metabolism: Pathology review
Disorders of fatty acid metabolism: Pathology review
Dyslipidemias: Pathology review
Glycogen storage disorders: Pathology review
Lysosomal storage disorders: Pathology review
Fatty acid oxidation
0 / 9 complete
0 / 3 complete
gluconeogenesis p. 76
metabolism of p. 45, 70, 87, 88
oxidation of p. 72, 72
synthesis p. 70
fatty acid p. 87
Our bodies are capable of surviving without food for long periods of time, at least 3-4 weeks with hydration!
The reason we can do that is that we can store our dietary fuels, and then break them down when needed to make energy in the form of adenosine triphosphate, or ATP.
Fat is one of the most important ways we store energy and the term “burning fat”, actually refers to fatty acid oxidation.
In fact, if two individuals were stranded in the Andes mountains with no food, the person with more fat content would survive longer - yet another reason to avoid working out.
The transfer of electrons in the form of hydrogen from these fatty acids to certain molecules, can then be used to generate ATP.
Before we can oxidize fat, it needs to be moved from storage sites to the cells that can use it. Fat is stored in adipocytes or fat cells as triglycerides, which are 3 fatty acids attached to a glycerol molecule.
Now, the free fatty acids can leave the fat cell, and enter the bloodstream, where they bind to a protein called albumin.
Fatty acid oxidation is the process your body uses to break down and uses fatty acids for energy. This process occurs in the mitochondria of your cells. During fatty acid oxidation, a fatty acid is broken down into two molecules of acetyl coenzyme A (CoA). These molecules are then used by the mitochondria to produce energy.
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