Fibrous dysplasia of bone

Summary of Fibrous dysplasia of bone
Fibrous dysplasia is a disorder where normal bone and marrow is replaced with fibrous tissue, resulting in the formation of bone that is weak and prone to expansion. This disease occurs along a broad clinical spectrum ranging from asymptomatic, incidental lesions to severe disabling disease. It can affect one bone (monostotic) or multiple (polyostotic), and may occur in isolation or in combination with cafe-au-lait skin macules and hyperfunctioning endocrinopathies, termed McCune-Albright syndrome.

Videos

Notes

Pathology

Musculoskeletal system

Pediatric musculoskeletal conditions
Musculoskeletal injuries and trauma
Bone disorders
Joint disorders
Muscular disorders
Neuromuscular junction disorders
Other autoimmune disorders
Musculoskeletal system pathology review

Assessments
Fibrous dysplasia of bone

Flashcards

0 / 5 complete

Questions

1 / 1 complete
High Yield Notes
16 pages
Flashcards

Fibrous dysplasia of bone

5 flashcards
Preview

A can be used to diagnose fibrous dysplasia of bone by using radioactive tracers which show the damaged areas of bone. 

Questions

USMLE® Step 1 style questions USMLE

1 questions
Preview

A 9-year-old girl is brought to the pediatrician’s office with several months of pain in deep in her thigh and arm. Her mother is also concerned that her breasts have grown considerably over the last year. On physical examination she has hyperpigmented patches over her left neck, back, and shoulder, poorly-defined, firm masses that are painful to palpation in the right thigh and left forearm and Tanner stage 3 breasts and Tanner stage 2 pubic hair. Bone biopsy of her affected forearm shows fibrous dysplasia.  Which of the following is the most likely underlying mutation causing the symptoms in this patient?