AssessmentsFibrous dysplasia of bone
Fibrous dysplasia of bone
A can be used to diagnose fibrous dysplasia of bone by using radioactive tracers which show the damaged areas of bone.
USMLE® Step 1 style questions USMLE
A 9-year-old girl is brought to the pediatrician’s office with several months of pain in deep in her thigh and arm. Her mother is also concerned that her breasts have grown considerably over the last year. On physical examination she has hyperpigmented patches over her left neck, back, and shoulder, poorly-defined, firm masses that are painful to palpation in the right thigh and left forearm and Tanner stage 3 breasts and Tanner stage 2 pubic hair. Bone biopsy of her affected forearm shows fibrous dysplasia. Which of the following is the most likely underlying mutation causing the symptoms in this patient?