Assessment of Gastroesophageal reflux disease (GERD): Video | Osmosis

Question

A 69-year-old man presents to the primary care physician with dysphagia. The patient reports progressive difficulty swallowing, now to the point where he has trouble tolerating liquids and sometimes vomits after eating. The patient has a significant history of alcohol abuse, 50-pack-year smoking history, as well as hypertension and hyperlipidemia. Temperature is 37°C (98.6°F), pulse is 68/min, respirations are 14/min and blood pressure is 130/82 mmHg. Physical exam shows a thin male with bitemporal wasting and non-tender anterior cervical lymphadenopathy. Oral and neck examination is unremarkable aside from poor dentition. Laboratory results are as follows:

Laboratory value	Result
CBC, Serum
Hemoglobin	11.2 g/dL
Hematocrit	33.6%
Leukocyte count	10,100 /mm3
Platelet count	149,000/mm3
MCV	72 fL
RDW	11.5-14.5%
Iron Studies, Serum
Serum Iron	90 μg/dL
Ferritin	Ferritin 170 ng/mL
Total iron binding capacity	220 μg/dL

A barium swallow study reveals an esophageal mass that significantly narrows the lumen in the middle of the esophagus. Which of the following pathologic features is most likely to be found on upper endoscopy?

Accepted Answer

Invasion of neoplastic squamous cells into the lamina propria

Answer

Columnar metaplasia with goblet cells&#160;

Answer

Columnar dysplasia with goblet cell crowding and invasion into the lamina propria

Answer

Loss of inhibitory ganglion cells in the myenteric plexus

Answer

Eosinophilic predominance and basophilic hyperplasia

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Gastroesophageal reflux disease (GERD)

Pathology

Eyes, ears, nose and throat