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Gilbert's syndrome

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Gastrointestinal system

Pathology

Peritoneum and peritoneal cavity
Upper gastrointestinal tract disorders
Lower gastrointestinal tract disorders
Liver, gallbladder and pancreas disorders
Gastrointestinal system pathology review

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Gilbert's syndrome

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High Yield Notes
6 pages
Flashcards

Gilbert's syndrome

7 flashcards
Questions

USMLE® Step 1 style questions USMLE

2 questions
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A 17-year-old overweight boy, who has recently begun a new diet plan, comes to his primary care physician because his friends have been telling him that he looks “a little yellow” sometimes. Medical history is noncontributory and physical examination shows no abnormalities. Laboratory studies show elevated unconjugated bilirubin concentration. A week later, his bilirubin concentration is measured as normal. Of the following mechanisms, which of the following best explains the pathogenesis of the most likely diagnosis?

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Summary
Gilbert's syndrome is a common genetic liver disorder that produces elevated levels of unconjugated bilirubin in the bloodstream due to the reduced activity of the enzyme Uridine 5'-diphospho-glucuronosyltransferase. This normally has no serious consequences, although mild jaundice may appear under conditions of exertion or stress.