Gilbert's syndrome
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High Yield Notes
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Flashcards
Gilbert's syndrome
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Questions
USMLE® Step 1 style questions USMLE
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A 25-year-old man comes to his outpatient provider seeking evaluation of jaundice. Two days ago, the patient participated in a marathon race. He had a similar episode in college after an episode of binge drinking. Past medical history is notable for seasonal allergies and hepatitis A infection, which he acquired one-year ago while travelling overseas. In the office, his temperature is 37.5°C (99.5°F), blood pressure is 118/65 mmHg, and pulse is 67/min. Physical examination shows scleral icterus and diffuse jaundice. Cardiac, pulmonary, and abdominal exams are noncontributory. Urinalysis reveals no significant findings. The patient’s blood work reveals the following findings:
Which of the following best explains the underlying cause of this patient’s condition?
| Laboratory value | Result |
| Hemoglobin | 14.2 mg.dL |
| Leukocyte count | 6,800/mm3 |
| Total bilirubin | 4.1 mg/dL |
| Conjugated bilirubin | 0.2 mg/dL |
| Alanine aminotransferase | 14 U/L |
| Aspartate aminotransferase | 17 U/L |
External References
First Aid
2024
2023
2022
2021
Gilbert syndrome p. 400, 401
Summary
Gilbert's syndrome is a genetic disorder that affects how the liver conjugates bilirubin. People with Gilbert's syndrome have mild jaundice, which unusually appears under stressful conditions. The disorder is typically passed down through families in an autosomal recessive pattern, meaning both parents will pass on the gene for a child to be affected.