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Glanzmann's thrombasthenia

Summary of Glanzmann's thrombasthenia
Glanzmann's thrombasthenia is an abnormality of the platelets. It is an extremely rare coagulopathy in which the platelets contain defective or low levels of glycoprotein IIb/IIIa, which is a receptor for fibrinogen. As a result, no fibrinogen bridging of platelets to other platelets can occur, and the bleeding time is significantly prolonged.




Hematological system

Heme synthesis disorders
Coagulation disorders
Platelet disorders
Mixed platelet and coagulation disorders
Thrombosis syndromes (hypercoagulability)
Leukemoid reaction
Dysplastic and proliferative disorders
Plasma cell dyscrasias
Hematological system pathology review

Glanzmann's thrombasthenia


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High Yield Notes
3 pages

Glanzmann's thrombasthenia

10 flashcards

To treat acute bleeding in patients with Glanzmann thrombasthenia, is the second line of treatment while platelet transfusion is the first line.


USMLE® Step 1 style questions USMLE

2 questions

USMLE® Step 2 style questions USMLE

1 questions

 A 4-year-old Native American girl is brought to the pediatrician's office by her grandmother because of multiple ecchymotic patches over both shoulders. Her medical history is relevant for multiple hospital admissions when she was born. When asked about the mother of the girl, the grandmother mentions that she was unable to come because of her work hours. Physical exam shows swollen gums, poor dental hygiene, and a  petechial rash over her face. Her  temperature is 36.4°C ( 97.52°F), pulse is 101/min, respirations are 17/min, blood pressure is 120/70 mmHg. Laboratory studies show prolonged bleeding time, but platelet count and coagulation tests are normal. Which of the following is the most likely cause of this patient's condition? 

External References