Glanzmann's thrombasthenia
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Glanzmann's thrombasthenia
Hematological system
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Microcytic anemia: Pathology review
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Platelet disorders: Pathology review
Mixed platelet and coagulation disorders: Pathology review
Thrombosis syndromes (hypercoagulability): Pathology review
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Assessments
Glanzmann's thrombasthenia
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High Yield Notes
3 pages
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Glanzmann's thrombasthenia
of complete
Questions
USMLE® Step 1 style questions USMLE
of complete
| Laboratory value | Result |
| Hematologic | |
| Hemoglobin | 12 g/dL |
| Hematocrit | 40% |
| Platelet count | 95,000/mm3 |
| Leukocyte count | 9,000/mm3 |
| Coagulation studies | |
| Prothrombin time (PT) | 12 seconds |
| Activated partial thromboplastin time (aPTT) | 29 seconds |
| Bleeding time* | 15 minutes |
Which of the following conditions is the patient at greatest risk of developing?
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Glanzmann thrombasthenia p. 419, 434
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Summary
Glanzmann's thrombasthenia is a rare autosomal recessive bleeding disorder caused by defects in platelet aggregation. In Glanzmann's thrombasthenia, platelets are deficient in the fibrinogen receptor GpIIb/IIIa necessary for proper platelet aggregation. This leads to easy bruising, mucosa bleeding, and prolonged bleeding from even minor cuts. It can also cause internal bleeding, which can be life-threatening.
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