Heart blocks: Pathology review

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Questions

USMLE® Step 1 style questions USMLE

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A 61-year-old man comes to the emergency department with two weeks of fevers and chills. He also reports a poor appetite and has noticed a weight loss of 2.3 kg (5 lb) over the past month. He also complains of malaise with intermittent headaches, muscle aches, and night sweats over this same time period. Medical history is significant for chronic kidney disease (CKD) stage II, due to hypertension. Medications include lisinopril and hydrochlorothiazide. He was born in India, and he does not drink alcohol or use recreational drugs. His temperature is 39.4°C (102.9°F), pulse is 45/min, respirations are 23/min, blood pressure is 100/50 mmHg, and oxygen saturation is 95% on room air. He appears ill. Physical exam shows a regularly irregular heartbeat with a high-pitched, early diastolic decrescendo murmur. Lung auscultation reveals crackles at the bilateral lung bases. Laboratory studies show renal function at baseline and normal cardiac enzymes. An ECG is obtained and shows the following:


Reproduced from: Wikimedia Commons

Which of the following is the most likely etiology of this patient’s clinical condition? 

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Mikey is a 22 year old male college student from Vermont who was sent to the emergency department after passing out.

His vital signs show a heart rate of 40 beats per minute and a blood pressure of 90/50. On examination, there is an erythematous circular rash with central clearing.

His friends mention they recently went on a hiking trip. His ECG is as follows.

Natasha is a 60 year old female with chronic hypertension, diabetes, and peripheral vascular disease who comes to the emergency room complaining of sudden-onset, squeezing retrosternal chest pain accompanied by shortness of breath and sweating.

Her ECG is as follows. On laboratory evaluation, her troponin levels are significantly elevated.

Alright, so the normal electrical activity of the heart starts in the sinoatrial or SA node located near the opening of the superior vena cava into the right atrium.

Electrical activity is then conducted through the atrium to the atrioventricular, or AV node, after which it goes through the Bundle of His, then the right and left branches of the Bundle, and finally through the Purkinje fibers which deliver the current to the right and left ventricles.

Now, normally there is delay in conduction at the AV node and the Bundle of His, which gives some time for ventricular filling before the ventricle contracts.

A “heart block”, or AV block, occurs when conduction is delayed for too long at the AV node or the bundle of His. Also, electrical activity may be blocked at the level of the bundle branches, which are called bundle branch blocks.

Sources

  1. "Pathophysiology of Heart Disease" Wolters Kluwer Health (2015)
  2. "Chou's Electrocardiography in Clinical Practice" Saunders (2008)
  3. "Clinical electrophysiology of atrioventricular block" Cardiol Clin (1983)
  4. "Left Bundle Branch Block: Current and Future Perspectives" Circ Arrhythm Electrophysiol (2020)
  5. "2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society" J Am Coll Cardiol (2019)
  6. "Bradycardias and atrioventricular conduction block" BMJ. 2002 (2002)
  7. "Observations on second degree atrioventricular block, including new criteria for the differential diagnosis between type I and type II block" The American Journal of Cardiology (1972)
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