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test 4

test 4

Diabetes insipidus

Diabetes mellitus: Clinical (To be retired)

Diabetes mellitus

Diabetes mellitus: Pathology review

Graves disease

Hyperthyroidism: Nursing Process (ADPIE)


Hyperthyroidism: Pathology review


Hyperparathyroidism: Nursing


Hypopituitarism: Clinical (To be retired)

Hypopituitarism: Pathology review


Hypothyroidism: Nursing Process (ADPIE)

Hypothyroidism: Pathology review

Metabolic acidosis

Metabolic alkalosis


Thyroid cancer

Thyroid nodules and thyroid cancer: Clinical (To be retired)

Thyroid nodules and thyroid cancer: Pathology review

Anemia: Clinical (To be retired)

Macrocytic anemia: Pathology review

Aplastic anemia

Warm autoimmune hemolytic anemia and cold agglutinin (NORD)

Disseminated intravascular coagulation

Acute disseminated encephalomyelitis


Hemophilia: Nursing Process (ADPIE)

Thrombocytopenia: Clinical (To be retired)

Heparin-induced thrombocytopenia

Immune thrombocytopenic purpura

Thrombotic thrombocytopenic purpura

Leukemia: Nursing Process (ADPIE)

Chronic leukemia

Leukemias: Pathology review

Acute leukemia

Leukemia: Clinical (To be retired)

Lymphomas: Pathology review

Lymphoma: Clinical (To be retired)

Hodgkin lymphoma

Non-Hodgkin lymphoma

Lymphatic system anatomy and physiology

Multiple endocrine neoplasia: Pathology review

Multiple endocrine neoplasia

Sickle cell disease (NORD)

Sickle cell disease: Clinical (To be retired)

Sickle-cell disease: Nursing Process (ADPIE)

Deep vein thrombosis

Deep vein thrombosis and pulmonary embolism: Pathology review

Von Willebrand disease

von Hippel-Lindau disease

Allergic rhinitis

Antibody classes

Pediatric allergies: Clinical (To be retired)

Food allergies and EpiPens: Information for patients and families (The Primary School)

Anaphylaxis: Nursing Process (ADPIE)


Appendicitis: Nursing Process (ADPIE)

Appendicitis: Pathology review


Appendicitis: Clinical (To be retired)

Gonorrhea & chlamydia: Nursing Process (ADPIE)

Chlamydia pneumoniae

Chlamydia trachomatis

Clostridium difficile (Pseudomembranous colitis)

Viral hepatitis: Pathology review

Viral hepatitis: Clinical (To be retired)

Hepatitis C virus


Hepatitis A and Hepatitis E virus

Herpes simplex virus

Herpesvirus medications

Human parainfluenza viruses


Antiretrovirals for HIV/AIDS - NRTIs & NNRTIs: Nursing Pharmacology

Antiretrovirals for HIV/AIDS - Protease inhibitors: Nursing Pharmacology

Antiretrovirals for HIV/AIDS - Integrase strand transfer inhibitors: Nursing Pharmacology

Human papillomavirus

Influenza virus

The flu vaccine: Information for patients and families


Legionella pneumophila (Legionnaires disease and Pontiac fever)

Borrelia burgdorferi (Lyme disease)

Lyme disease: Nursing Process (ADPIE)

Lyme Disease

Meningitis: Nursing Process (ADPIE)


Meningitis, encephalitis and brain abscesses: Clinical (To be retired)

Epstein-Barr virus (Infectious mononucleosis)

Pelvic inflammatory disease

Pelvic inflammatory disease (PID): Nursing Process (ADPIE)

Pneumonia: Pathology review


Pneumonia: Clinical (To be retired)

Mycobacterium tuberculosis (Tuberculosis)

Tuberculosis: Pathology review

Urinary tract infections (UTI): Nursing Process (ADPIE)

Urinary tract infections: Pathology review

Lower urinary tract infection

Urinary tract infections: Clinical (To be retired)

Gardnerella vaginalis (Bacterial vaginosis)

Chickenpox (Varicella): Nursing Process (ADPIE)

Varicella zoster virus




0 / 12 complete

USMLE® Step 1 questions

0 / 2 complete

High Yield Notes

5 pages



of complete


USMLE® Step 1 style questions USMLE

of complete

A 13-year-old female presents to the emergency room due to persistent bleeding. Earlier in the day, she had a wisdom tooth extracted at the dentist’s office. After the procedure, the patient continued to bleed from the extraction site despite application of manual pressure. She is otherwise healthy and does not take any medications. The patient’s parent reports that she was adopted from Eastern Europe, and her family history is unknown. Laboratory testing is obtained and reveals the following:

Which of the following best describes the inheritance pattern of this patient’s clinical condition?


Content Reviewers

Rishi Desai, MD, MPH


Tanner Marshall, MS

The word “hemophilia” is a combination of the Greek words for “blood” and “love”, a way of saying that people with hemophilia “love to bleed”, or rather that it’s hard to stop bleeding. This is because the process called hemostasis, literally meaning to stop the flow of blood, is impaired.

Normally, after a cut and damage to the endothelium, or the inner lining of blood vessel walls, there’s an immediate vasoconstriction or narrowing of the blood vessel which limits the amount of blood flow. After that some platelets adhere to the damaged vessel wall, and become activated and then recruit additional platelets to form a plug. The formation of the platelet plug is called primary hemostasis.

After that, the coagulation cascade is activated. First off in the blood there’s a set of clotting factors—most of which are proteins synthesized by the liver, and usually these are inactive and just floating around the blood. The coagulation cascade starts when one of these proteins gets proteolytically cleaved. This active protein then proteolytically cleaves and activates the next clotting factor, and so on. This cascade has a great degree of amplification and takes only a few minutes from injury to clot formation. The final step is activation of the protein fibrinogen to fibrin, which deposits and polymerizes to form a mesh around the platelets. So these steps leading up to fibrin reinforcement of the platelet plug make up the process called secondary hemostasis and results in a hard clot at the site of the injury.

In most cases of hemophilia there is a decrease in the amount or function of one or more of the clotting factors which makes secondary hemostasis less effective and allows more bleeding to happen.


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