00:00 / 00:00
0 / 9 complete
0 / 6 complete
0 / 6 complete
|Hemoglobin||12.5 g/dL |
|Leukocyte count ||8000 mm3 |
|Platelet count ||230,000 mm3 |
|Viral profile |
|HAV IgM ||Negative|
|HAV IgG ||Positive|
|HBV IgG ||Positive|
|HCV IgG ||Positive|
|HCV RNA ||100,000,000 IU/ml |
contraindicated in pregnancy p. 201
hepatitis p. 723
hepatitis C p. 201
purine synthesis p. 34
ribavirin p. 201
Now, viral hepatitis can be acute or chronic.
Chronic hepatitis lasts for more than six months, sometimes even for decades.
Alright, so, HCV is a single stranded RNA virus.
What this means is that HCV inject its RNA into the host’s cell and it can immediately use its host’s ribosomes and translate the proteins needed to make more viruses, like capsomere proteins and enzymes like RNA-dependent RNA polymerase.
HBV on the other hand is a double stranded DNA virus.
Once the DNA gets injected into a new cell, it enters the cell’s nucleus and is replicated by the host cell’s machinery.
It’s also transcribed into several messenger RNAs and a pregenomic RNA, and then the messenger RNAs are used to make capsomere proteins and enzymes like DNA polymerase.
DNA polymerase uses the pregenomic RNA to synthesize new copies of the viral DNA, which is combined with the capsomere proteins to assemble new viruses.
With each type of virus, whether it’s RNA or DNA, it’s turning your own cells into virus making factories and pumping out new viruses.
This process strains, damages and potentially kills the infected hepatocytes.
The medications for hepatitis can be divided into two broad categories: those that clear the virus from the body (i.e. antivirals) and those that work to protect the liver from further damage (i.e. hepatoprotectives).
Antiviral medications for hepatitis include pegylated interferon, ribavirin, and telbivudine. These medications are typically used in combination with each other and are very effective at clearing the virus from the body.
Hepatoprotective medications for hepatitis include milk thistle, ursodeoxycholic acid, and vitamin E. These medications protect the liver from further damage and can be quite effective at preventing or slowing the progression of liver disease.
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