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Hodgkin lymphoma p. 436
bleomycin for p. 447
non-Hodgkin vs p. 436
oncogenic microbes and p. 224
paraneoplastic cerebellar degeneration and p. 221
types of p. 730
vinca alkaloids for p. 449
Hodgkin lymphoma vs p. 436
The term Hodgkin lymphoma -can be broken down. Lymph- refers to lymphocytes and oma- refers to a tumor.
In case you’re wondering, the disease gets its name from the English physician Thomas Hodgkin, who first described these tumors.
B-cell development begins in the bone marrow, which is a primary lymphoid organ.
The naive B cells then leave the bone marrow and circulate in the blood and eventually settle down in lymph nodes.
B-cells differentiate into plasma cells, which are found in the medulla or center of the lymph nodes.
Plasma cells release antibodies or immunoglobulins.
Antibodies bind to pathogens like viruses and bacteria, to help destroy or remove them.
In fact, the combination of surface proteins that are on an immune cell works a bit like an ID card.
Now, a B cell is activated when it encounters an antigen that binds just perfectly to its surface immunoglobulin.
Hodgkin lymphoma is a cancer of the lymphatic system typically arising from B-cells. It is commonly seen in immunodeficient individuals, such as those with HIV, and is usually associated with the Epstein-Barr virus. Symptoms may include fever, night sweats, weight loss, and painless and swollen cervical lymph nodes.
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