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Hyperimmunoglobulin E syndrome

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Hyperimmunoglobulin E syndrome

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High Yield Notes
10 pages
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Hyperimmunoglobulin E syndrome

9 flashcards
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USMLE® Step 1 style questions USMLE

1 questions

USMLE® Step 2 style questions USMLE

1 questions
Preview

A 4-year-old is brought to the pediatric dermatologist because of a persistent rash for 4 years. The mother reports that the child has had similar rashes since birth. Subsequently, the boy has had numerous skin infections and abscesses which, when cultured, grow Staphylococcus aureus. Physical examination shows coarse facies and scoliosis. Which of the following immunoglobulins is most likely to be elevated?


External References
Summary
Job syndrome, or autosomal dominant hyper-IgE syndrome is a result of a STAT3 mutation. A deficiency of Th17 cells causes impaired recruitment of neutrophils to sites of infection, leading to coarse facies, non-inflamed staphylococcal abscess, retained primary teeth, and eczema