Hyperimmunoglobulin E syndrome
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Hyperimmunoglobulin E syndrome
Immune system
Disorders associated with immunodeficiency
Asplenia
Common variable immunodeficiency
Hyperimmunoglobulin E syndrome
IgG subclass deficiency
Isolated primary immunoglobulin M deficiency
Selective immunoglobulin A deficiency
X-linked agammaglobulinemia
Adenosine deaminase deficiency
Ataxia-telangiectasia
Hyper IgM syndrome
Severe combined immunodeficiency
Wiskott-Aldrich syndrome
Complement deficiency
Hereditary angioedema
Chediak-Higashi syndrome
Chronic granulomatous disease
Leukocyte adhesion deficiency
DiGeorge syndrome
Thymic aplasia
HIV and AIDS
Immune system organ disorders
Immunologically mediated disorders
Cytomegalovirus infection after transplant (NORD)
Graft-versus-host disease
Post-transplant lymphoproliferative disorders (NORD)
Transplant rejection
Anaphylaxis
Asthma
Food allergy
Type I hypersensitivity
Autoimmune hemolytic anemia
Goodpasture syndrome
Graves disease
Hemolytic disease of the newborn
Immune thrombocytopenia
Myasthenia gravis
Pemphigus vulgaris
Rheumatic heart disease
Type II hypersensitivity
Poststreptococcal glomerulonephritis
Serum sickness
Systemic lupus erythematosus
Type III hypersensitivity
Contact dermatitis
Graft-versus-host disease
Type IV hypersensitivity
Infectious disorders
Immune system pathology review
Immunodeficiencies: Combined T-cell and B-cell disorders: Pathology review
Immunodeficiencies: Phagocyte and complement dysfunction: Pathology review
Immunodeficiencies: T-cell and B-cell disorders: Pathology review
HIV and AIDS: Pathology review
Blood transfusion reactions and transplant rejection: Pathology review
Assessments
Flashcards
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USMLE® Step 1 questions
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High Yield Notes
10 pages



Flashcards
Hyperimmunoglobulin E syndrome
0 of 9 complete
Questions
USMLE® Step 1 style questions USMLE
0 of 1 complete
A 20-year-old man presents to his primary care physician due to cough and shortness of breath. The patient’s cough is productive of yellow, blood-tinged sputum. The patient has had recurrent pneumonia over the past ten years treated with oral antibiotics. Past medical history is significant for eczema since the newborn period, as well as recurrent pustular and eczematous rashes on the face and scalp throughout childhood. He underwent extraction of his primary teeth at the age of 14 years due to failure of eruption of secondary teeth. Family history is significant for similar symptoms in the patient’s mother. Temperature is 38.7 C (101.7 F), pulse is 90/min, respirations are 25/min and blood pressure is 110/70 mmHg. Physical examination demonstrates a broad nose, prominent lower lip, deep-set eyes with a prominent forehead, and a rough complexion with exaggerated pore size. Auscultation of lungs demonstrates bilateral rales in the lower lung fields and decreased breath sounds at the right lung base. Which of the following laboratory abnormalities is most likely to be observed in this patient?
External References
First Aid
2024
2023
2022
2021
Autosomal dominant disorders
hyper-IgE syndrome p. 114
Autosomal dominant hyper-IgE syndrome
Eczema
hyper-IgE syndrome p. 114, 722
Hyper-IgE syndrome
presentation p. 722
Summary
Hyperimmunoglobulin E syndrome (HIES) is a genetic disorder caused by STAT3 gene mutation. It is characterized by Th17 cell deficiency, impaired neutrophil recruitment to sites of infection, and increased serum IgE concentrations. People with HIES physically present with coarse facial features, recurrent staphylococcal abscesses, retained primary teeth, and eczema.