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Congenital adrenal hyperplasia
Primary adrenal insufficiency
Adrenal cortical carcinoma
Thyroglossal duct cyst
Thyroid eye disease (NORD)
Toxic multinodular goiter
Euthyroid sick syndrome
Subacute granulomatous thyroiditis
Growth hormone deficiency
Constitutional growth delay
Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
Premature ovarian failure
Polycystic ovary syndrome
Androgen insensitivity syndrome
Autoimmune polyglandular syndrome type 1 (NORD)
Multiple endocrine neoplasia
Pancreatic neuroendocrine neoplasms
Opsoclonus myoclonus syndrome (NORD)
Adrenal insufficiency: Pathology review
Adrenal masses: Pathology review
Hyperthyroidism: Pathology review
Hypothyroidism: Pathology review
Thyroid nodules and thyroid cancer: Pathology review
Parathyroid disorders and calcium imbalance: Pathology review
Diabetes mellitus: Pathology review
Cushing syndrome and Cushing disease: Pathology review
Pituitary tumors: Pathology review
Hypopituitarism: Pathology review
Diabetes insipidus and SIADH: Pathology review
Multiple endocrine neoplasia: Pathology review
Neuroendocrine tumors of the gastrointestinal system: Pathology review
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0 / 9 complete
|Creatine kinase (CK)||145 U/L|
|Aspartate aminotransferase||66 U/L|
|Alanine aminotransferase||77 U/L|
hypothyroidism p. 250
hypothyroidism with p. 347
maternal hypothyroidism from p. 347
amiodarone and p. 329
anemia p. 428
in anemia taxonomy p. 425
carpal tunnel syndrome and p. 456
as drug reaction p. 250
hormone replacement p. 362
lithium p. 598
hypothyroidism p. 347
hypothyroidism in p. 348
hypothyroidism p. 250
Brittany Norton, MFA
Tanner Marshall, MS
In hypothyroidism, ‘hypo' refers to having too little, and ‘thyroid’ refers to thyroid hormone, so hypothyroidism refers to a condition where there’s a lack of thyroid hormones.
Normally, the hypothalamus, which is located at the base of the brain, detects low blood levels of thyroid hormones and releases thyrotropin-releasing hormone into the hypophyseal portal system - which is a network of capillaries linking the hypothalamus to the anterior pituitary.
The anterior pituitary then releases thyroid-stimulating hormone, also called thyrotropin or simply TSH.
TSH stimulates the thyroid gland which is a gland located in the neck that looks like two thumbs hooked together in the shape of a “V”.
The thyroid gland is made up of thousands of follicles, which are small spheres lined with follicular cells. Follicular cells convert thyroglobulin, a protein found in follicles, into two iodine-containing hormones, triiodothyronine or T3, and thyroxine or T4.
Once released from the thyroid gland, these hormones enter the blood and bind to circulating plasma proteins.
Only a small amount of T3 and T4 will travel unbound in the blood, and these two hormones get picked up by nearly every cell in the body.
Once inside the cell T4 is mostly converted into T3, and it can exert its effect. T3 speeds up the cell’s basal metabolic rate.
So as an example, the cell might produce more proteins and burn up more energy in the form of sugars and fats. It’s as if the cells are in a bit of frenzy.
T3 increases cardiac output, stimulates bone resorption - thinning out the bones, and activates the sympathetic nervous system, the part of the nervous system responsible for our ‘fight-or-flight’ response.
Hypothyroidism refers to a condition where there's a lack of thyroid hormones (triiodothyronine (T3) and thyroxine (T4)), which normally help control the body's metabolism.
Hypothyroidism can be primary or secondary. In primary hypothyroidism, the thyroid gland isn't working properly, because of an autoimmune disease like Hashimoto's thyroiditis, hyperthyroidism treatment, or a congenital defect. In secondary hypothyroidism, either the anterior pituitary gland or the hypothalamus is the problem, usually because of a tumor or damage from surgery.
Symptoms of Hypothyroidism include weight gain, mental slowness, swelling in the skin and soft tissues, and a slower heart rate.
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