Hypothyroidism and thyroiditis: Clinical (To be retired)
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Hypothyroidism and thyroiditis: Clinical (To be retired)
Medicine and surgery
Allergy and immunology
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Cardiology, cardiac surgery and vascular surgery
Coronary artery disease: Clinical (To be retired)
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Syncope: Clinical (To be retired)
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Endocrinology and ENT (Otolaryngology)
Diabetes mellitus: Clinical (To be retired)
Hyperthyroidism: Clinical (To be retired)
Hypothyroidism and thyroiditis: Clinical (To be retired)
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Hyperthyroidism medications
Hypothyroidism medications
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Gastroenterology and general surgery
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Laxatives and cathartics
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Pneumonia: Clinical (To be retired)
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Protein synthesis inhibitors: Aminoglycosides
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Miscellaneous cell wall synthesis inhibitors
Protein synthesis inhibitors: Tetracyclines
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Anatomy clinical correlates: Clavicle and shoulder
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Anatomy clinical correlates: Wrist and hand
Anatomy clinical correlates: Median, ulnar and radial nerves
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Anatomy clinical correlates: Hip, gluteal region and thigh
Anatomy clinical correlates: Knee
Anatomy clinical correlates: Leg and ankle
Anatomy clinical correlates: Foot
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Hypothyroidism and thyroiditis: Clinical (To be retired)
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Content Reviewers
Rishi Desai, MD, MPHContributors
Sam Gillespie, BSc
Hypothyroidism is a condition that’s caused by having insufficient thyroid hormones.
Thyroid hormone production is under the control of the hypothalamus and the pituitary.
The hypothalamus secretes thyrotropin releasing hormone, or TRH, and TRH stimulates the anterior pituitary to secrete thyroid-stimulating hormone, or TSH.
TSH then binds to TSH receptors, which makes the thyroid secrete thyroxine, or T4 and triiodothyronine, or T3, in the blood. But this is not a one-way street - there’s also negative feedback happening, meaning when thyroid hormone levels rise, that inhibits the production of TSH and TRH, halting further production of T3 and T4 - to keep everything in balance.
Normally, some thyroid hormones travel through the bloodstream bound to thyroid binding globulin, and some are in their free form. And the thyroid actually makes more T4 than T3, and that T4 is converted to the more potent T3 in the periphery.
Thyroid hormones then increase the rate of metabolism in all cells, so they make us think, move, and talk faster, and they also increase heat generation. They also activate the sympathetic nervous system, the part of the nervous system responsible for our ‘fight-or-flight’ response, increasing cardiac output.
So with hypothyroidism, it’s like the entire body is functioning in slow motion - but this happens gradually, so it can take years before symptoms are even recognized. These include weight gain despite a loss in appetite because of the lower basal metabolic rate; cold sensitivity because the body is producing less heat; and slower heart rate, mental slowness, lethargy, and constipation because of the decreased effect of thyroid hormones on the sympathetic nervous system.
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