Imaging features of COVID-19 (LifeBridge Health)

Transcript

As of March 16th, so in just the first three months of the outbreak, there have been 167,511 cases of COVID-19 and 6,606 deaths, working out to a mortality rate of 3.9%.

On top of that, every case of COVID-19, leads to roughly 2.3 new cases, meaning that the outbreak is still spreading.

Many countries have been affected, and there are numerous cases of community spread, meaning that individuals are getting sick without being around any sick contacts or having traveled to outbreak areas.

In that context, healthcare workers need diagnostic tools to investigate cases of potential COVID-19 that are both sensitive and specific.

The gold standard for diagnosis of COVID-19 is RT-PCR, or reverse transcription polymerase chain reaction.

In the early days of the epidemic in China RT-PCR was only 30 to 70% sensitive whereas Chest CT was reportedly much more sensitive in that context.

However, more recent data from the US labs at the University of Washington suggests that second generation COVID RT-PCR tests are faring much better, with 95%+ sensitivity.

Despite its usefulness in the early days of the epidemic in China, Chest CT findings are no longer part of the diagnostic criteria for COVID.

There are still clearly issues with access to RT-PCR and related wait times in the US and elsewhere.

Nevertheless, over the past several weeks, several major US radiology societies have come out with statements making it clear that CT should be used sparingly in COVID and only when it will impact management.

However, because there will be certain cases when imaging is indicated, as well as patients imaged for other reasons whose scans reveal findings potentially suggestive of COVID, it is essential that healthcare providers be familiar with the imaging features of the infection.

Typically, when a patient has symptoms of COVID-19, like fever, cough, or shortness of breath, they may get a chest X-ray.

The most common abnormal finding is “ground glass” opacities, meaning that some portions of the lungs look like a “hazy” shade of gray instead of being black with fine white lung markings for blood vessels.

It looks a bit like frosted glass, like a window in the wintertime.

It is important to note, however, that chest X-rays are not very sensitive for COVID-19 and can yield false negatives.

Now compared to chest X-rays, chest CT gives a much more detailed view.

The most common CT finding in COVID-19 are those ground-glass opacities scattered throughout the lungs.

They represent tiny air-sacs or alveoli getting filled with fluid, and turning a shade of grey on a CT scan.

In severe or more advanced infections, more and more fluid will accumulate in the lobes of the lungs, so the ground glass appearance will progress to a solid white “consolidation.”

Finally, there’s a finding called the “crazy paving” pattern due to swelling of the interstitial space along the walls of the lung lobules.

This makes the walls look thicker, like white lines against the hazy, ground glass background.