Intraductal papilloma

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Summary of Intraductal papilloma

Intraductal papillomas of the breast are small benign papillary tumors in the lactiferous ducts of the breast of premenopausal women, and are found just beneath the areola. They are the most common cause of serous or bloody discharge from the female breast, and cause a slightly (1.5-2x) increased risk of developing breast cancer later in life. Histology shows fibrovascular projections lined by epithelial and myoepithelial cells. The condition needs to be differentiated from a papillary carcinoma, which also presents with bloody nipple discharge.

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Intraductal papilloma

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Intraductal papilloma

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Preview

A 30-year-old woman comes to the office because she started to notice some bloody discharge from her left breast one week ago. She does not have have discharge from her right breast. She is otherwise in good health, takes no medications, and denies any recent trauma. Physical examination does not show any discrete mass, but some serosanguinous discharge is elicited by squeezing the nipple. There are no changes to the skin. Ultrasound of the breast shows a single nodule within one of the ducts near the nipple. Which of the following is the most likely diagnosis?

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