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JC virus (Progressive multifocal leukoencephalopathy)
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HIV-positive adults p. 174
polyomaviruses p. 161
rituximab p. 449
In progressive multifocal leukoencephalopathy, progressive means that the disease worsens over time, multifocal means the disease affects multiple locations, leuko refers to white, and encephalopathy refers to a disease of the brain.
If we look at a cross section of the brain, it can be divided into two areas: the outermost area is the grey matter, which is made up of neuron cell bodies, and the innermost area is the white matter, which is made up of the axons that come off of the neuron cell bodies.
The axons transmit electrical impulses to the next neuron in the series.
The axons are surrounded by a fatty protective sheath called myelin that helps increase the speed at which electrical impulses are sent.
Myelin is produced by a special type of cells called oligodendrocytes.
JC virus is a non-enveloped virus with closed circular double-stranded DNA genome.
It’s thought that the virus is transmitted from person to person through the respiratory and gastrointestinal tract, and that it then moves through the bloodstream and eventually reaches kidney epithelial cells.
So to be clear, the virus is not eliminated, but instead it remains latent in the kidneys, meaning that it isn’t dividing and causing disease.
And It turns out that the vast majority of the population is infected by JC virus - that might include you!
Progressive multifocal leukoencephalopathy (PML) is a rare, often fatal demyelinating disease of the brain, caused by JC virus. JC virus is a non-enveloped, double-stranded DNA virus that can be found latent and harmless in most adults.
However, in people with weakened immune systems, the virus can cause PML, in which the white matter in the brain gets destroyed, leading to progressive and irreversible axon demyelination that presents with motor and cognitive neurological symptoms
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