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Lordosis, kyphosis, and scoliosis
Osteomalacia and rickets
Paget disease of bone
Calcium pyrophosphate deposition disease (pseudogout)
Juvenile idiopathic arthritis
Inclusion body myopathy
Degenerative disc disease
Spinal disc herniation
Achilles tendon rupture
Anterior cruciate ligament injury
Iliotibial band syndrome
Patellar tendon rupture
Patellofemoral pain syndrome
Carpal tunnel syndrome
Thoracic outlet syndrome
Radial head subluxation (Nursemaid elbow)
Rotator cuff tear
Lambert-Eaton myasthenic syndrome
Limited systemic sclerosis (CREST syndrome)
Mixed connective tissue disease
Systemic lupus erythematosus
Developmental dysplasia of the hip
Osgood-Schlatter disease (traction apophysitis)
Slipped capital femoral epiphysis
Back pain: Pathology review
Bone disorders: Pathology review
Bone tumors: Pathology review
Gout and pseudogout: Pathology review
Muscular dystrophies and mitochondrial myopathies: Pathology review
Myalgias and myositis: Pathology review
Neuromuscular junction disorders: Pathology review
Pediatric musculoskeletal disorders: Pathology review
Rheumatoid arthritis and osteoarthritis: Pathology review
Scleroderma: Pathology review
Seronegative and septic arthritis: Pathology review
Sjogren syndrome: Pathology review
Systemic lupus erythematosus (SLE): Pathology review
Myasthenia Gravis & Lambert-Eaton Myasthenic Syndrome
In Lambert-Eaton myasthenic syndrome, myasthenia refers to muscle weakness, and Lambert-Eaton refers to Edward Lambert and Lealdes Eaton, the two physicians who first described the condition.
Lambert-Eaton myasthenic syndrome is a rare autoimmune disease that attacks the peripheral nervous system, causing muscle weakness, and actually improves temporarily after repeated use of the muscle.
The nervous system is divided into the central nervous system, which is the brain and spinal cord, and the peripheral nervous system, which includes all the nerves that connect the central nervous system to the muscles and organs.
The peripheral nervous system can then further be divided into the somatic nervous system, which controls voluntary movement of our skeletal muscles, and the autonomic nervous system, which is even further divided into the sympathetic and the parasympathetic, and controls the involuntary movement of the smooth muscles and glands of our organs.
Now, to better understand Lambert-Eaton myasthenic syndrome, let’s review normal skeletal muscle contraction at the cellular level.
First you’ve got your motor neurons, which have voltage-gated calcium channels in their membranes.
Whenever a motor neuron receives an electrical impulse from the brain, these channels open up and let calcium inside.
The increased intracellular calcium concentration triggers the release of small vesicles that contain the neurotransmitter acetylcholine into the neuromuscular junction.
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