Lambert-Eaton myasthenic syndrome
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Lambert-Eaton myasthenic syndrome
Pathology
Bone disorders
Osteomyelitis
Bone tumors
Chondrosarcoma
Osteochondroma
Achondroplasia
Arthrogryposis
Cleidocranial dysplasia
Club foot
Craniosynostosis
Flat feet
Genu valgum
Genu varum
Osteogenesis imperfecta
Pectus excavatum
Pigeon toe
Lordosis, kyphosis, and scoliosis
Osteomalacia and rickets
Osteopetrosis
Osteoporosis
Osteosclerosis
Paget disease of bone
Musculoskeletal injuries and trauma
Degenerative disc disease
Sciatica
Spinal disc herniation
Spondylolisthesis
Spondylolysis
Achilles tendon rupture
Anterior cruciate ligament injury
Iliotibial band syndrome
Meniscus tear
Patellar tendon rupture
Patellofemoral pain syndrome
Sprained ankle
Unhappy triad
Compartment syndrome
Rhabdomyolysis
Carpal tunnel syndrome
Erb-Duchenne palsy
Klumpke paralysis
Sciatica
Thoracic outlet syndrome
Ulnar claw
Winged scapula
Carpal tunnel syndrome
Dislocated shoulder
Erb-Duchenne palsy
Klumpke paralysis
Radial head subluxation (Nursemaid elbow)
Rotator cuff tear
Thoracic outlet syndrome
Ulnar claw
Winged scapula
Musculoskeletal system pathology review
Back pain: Pathology review
Bone disorders: Pathology review
Bone tumors: Pathology review
Gout and pseudogout: Pathology review
Muscular dystrophies and mitochondrial myopathies: Pathology review
Myalgias and myositis: Pathology review
Neuromuscular junction disorders: Pathology review
Pediatric musculoskeletal disorders: Pathology review
Rheumatoid arthritis and osteoarthritis: Pathology review
Scleroderma: Pathology review
Seronegative and septic arthritis: Pathology review
Sjogren syndrome: Pathology review
Systemic lupus erythematosus (SLE): Pathology review
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Lambert-Eaton myasthenic syndrome
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Lambert-Eaton myasthenic syndrome
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USMLE® Step 1 style questions USMLE
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Reproduced from: Radiopaedia.org
Laboratory testing reveals a creatinine kinase level of 75 U/L. Which of the following additional examination findings will most likely be present in this patient?
External References
First Aid
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Calcium channels
Lambert-Eaton myasthenic syndrome p. 221
Dry mouth
Lambert-Eaton myasthenic syndrome p. 484
Erectile dysfunction p. 590
Lambert-Eaton myasthenic syndrome p. 483
Lambert-Eaton myasthenic syndrome p. 484
autoantibody p. 113
as paraneoplastic syndrome p. 221
small cell lung cancer p. 709
Sexual dysfunction p. 590
Lambert-Eaton myasthenic syndrome p. 483
Small cell lung cancer p. 732
Lambert-Eaton myasthenic syndrome p. 484
Transcript
Content Reviewers
In Lambert-Eaton myasthenic syndrome, myasthenia refers to muscle weakness, and Lambert-Eaton refers to Edward Lambert and Lealdes Eaton, the two physicians who first described the condition.
Lambert-Eaton myasthenic syndrome is a rare autoimmune disease that attacks the peripheral nervous system, causing muscle weakness, and actually improves temporarily after repeated use of the muscle.
The nervous system is divided into the central nervous system, which is the brain and spinal cord, and the peripheral nervous system, which includes all the nerves that connect the central nervous system to the muscles and organs.
The peripheral nervous system can then further be divided into the somatic nervous system, which controls voluntary movement of our skeletal muscles, and the autonomic nervous system, which is even further divided into the sympathetic and the parasympathetic, and controls the involuntary movement of the smooth muscles and glands of our organs.
Now, to better understand Lambert-Eaton myasthenic syndrome, let’s review normal skeletal muscle contraction at the cellular level.
First you’ve got your motor neurons, which have voltage-gated calcium channels in their membranes.
Whenever a motor neuron receives an electrical impulse from the brain, these channels open up and let calcium inside.
The increased intracellular calcium concentration triggers the release of small vesicles that contain the neurotransmitter acetylcholine into the neuromuscular junction.
Acetylcholine goes from the neuron over to the nicotinic receptors on muscle cell membranes.
Sources
- "Robbins Basic Pathology" Elsevier (2017)
- "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
- "Pathophysiology of Disease: An Introduction to Clinical Medicine 8E" McGraw-Hill Education / Medical (2018)
- "CURRENT Medical Diagnosis and Treatment 2020" McGraw-Hill Education / Medical (2019)
- "Available treatment options for the management of Lambert-Eaton myasthenic syndrome" Expert Opinion on Pharmacotherapy (2006)
- "Available treatment options for the management of Lambert-Eaton myasthenic syndrome" Expert Opinion on Pharmacotherapy (2006)
- "Lambert-Eaton Myasthenic Syndrome" Seminars in Neurology (2004)
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