Lambert-Eaton myasthenic syndrome
21,581views
00:00 / 00:00
Videos
Notes
Lambert-Eaton myasthenic syndrome
Pathology
Central nervous system disorders
Spina bifida
Chiari malformation
Dandy-Walker malformation
Syringomyelia
Tethered spinal cord syndrome
Aqueductal stenosis
Septo-optic dysplasia
Cerebral palsy
Spinocerebellar ataxia (NORD)
Transient ischemic attack
Ischemic stroke
Intracerebral hemorrhage
Epidural hematoma
Subdural hematoma
Subarachnoid hemorrhage
Saccular aneurysm
Arteriovenous malformation
Broca aphasia
Wernicke aphasia
Wernicke-Korsakoff syndrome
Kluver-Bucy syndrome
Concussion and traumatic brain injury
Shaken baby syndrome
Epilepsy
Febrile seizure
Early infantile epileptic encephalopathy (NORD)
Tension headache
Cluster headache
Migraine
Idiopathic intracranial hypertension
Trigeminal neuralgia
Cavernous sinus thrombosis
Alzheimer disease
Vascular dementia
Frontotemporal dementia
Lewy body dementia
Creutzfeldt-Jakob disease
Normal pressure hydrocephalus
Torticollis
Essential tremor
Restless legs syndrome
Parkinson disease
Huntington disease
Opsoclonus myoclonus syndrome (NORD)
Multiple sclerosis
Central pontine myelinolysis
Acute disseminated encephalomyelitis
Transverse myelitis
JC virus (Progressive multifocal leukoencephalopathy)
Adult brain tumors
Acoustic neuroma (schwannoma)
Pituitary adenoma
Pediatric brain tumors
Brain herniation
Brown-Sequard Syndrome
Cauda equina syndrome
Treponema pallidum (Syphilis)
Vitamin B12 deficiency
Syringomyelia
Friedreich ataxia
Neurogenic bladder
Meningitis
Neonatal meningitis
Encephalitis
Brain abscess
Epidural abscess
Cavernous sinus thrombosis
Creutzfeldt-Jakob disease
Central and peripheral nervous system disorders
Sturge-Weber syndrome
Tuberous sclerosis
Neurofibromatosis
von Hippel-Lindau disease
Amyotrophic lateral sclerosis
Peripheral nervous system disorders
Spinal muscular atrophy
Poliovirus
Guillain-Barre syndrome
Charcot-Marie-Tooth disease
Trigeminal neuralgia
Bell palsy
Winged scapula
Thoracic outlet syndrome
Carpal tunnel syndrome
Ulnar claw
Erb-Duchenne palsy
Klumpke paralysis
Sciatica
Myasthenia gravis
Lambert-Eaton myasthenic syndrome
Autonomic nervous system disorders
Orthostatic hypotension
Horner syndrome
Nervous system pathology review
Congenital neurological disorders: Pathology review
Headaches: Pathology review
Seizures: Pathology review
Cerebral vascular disease: Pathology review
Traumatic brain injury: Pathology review
Spinal cord disorders: Pathology review
Dementia: Pathology review
Central nervous system infections: Pathology review
Movement disorders: Pathology review
Neuromuscular junction disorders: Pathology review
Demyelinating disorders: Pathology review
Adult brain tumors: Pathology review
Pediatric brain tumors: Pathology review
Neurocutaneous disorders: Pathology review
Assessments
Lambert-Eaton myasthenic syndrome
Flashcards
0 / 9 complete
USMLE® Step 1 questions
0 / 2 complete
High Yield Notes
5 pages
Flashcards
Lambert-Eaton myasthenic syndrome
of complete
Questions
USMLE® Step 1 style questions USMLE
of complete
Reproduced from: Radiopaedia.org
Laboratory testing reveals a creatinine kinase level of 75 U/L. Which of the following additional examination findings will most likely be present in this patient?
Memory Anchors and Partner Content
External References
First Aid
2022
2021
2020
2019
2018
2017
2016
Calcium channels
Lambert-Eaton myasthenic syndrome p. 221
Dry mouth
Lambert-Eaton myasthenic syndrome p. 484
Erectile dysfunction p. 590
Lambert-Eaton myasthenic syndrome p. 483
Lambert-Eaton myasthenic syndrome p. 484
autoantibody p. 113
as paraneoplastic syndrome p. 221
small cell lung cancer p. 709
Sexual dysfunction p. 590
Lambert-Eaton myasthenic syndrome p. 483
Small cell lung cancer p. 732
Lambert-Eaton myasthenic syndrome p. 484
External Links
Transcript
In Lambert-Eaton myasthenic syndrome, myasthenia refers to muscle weakness, and Lambert-Eaton refers to Edward Lambert and Lealdes Eaton, the two physicians who first described the condition.
Lambert-Eaton myasthenic syndrome is a rare autoimmune disease that attacks the peripheral nervous system, causing muscle weakness, and actually improves temporarily after repeated use of the muscle.
The nervous system is divided into the central nervous system, which is the brain and spinal cord, and the peripheral nervous system, which includes all the nerves that connect the central nervous system to the muscles and organs.
The peripheral nervous system can then further be divided into the somatic nervous system, which controls voluntary movement of our skeletal muscles, and the autonomic nervous system, which is even further divided into the sympathetic and the parasympathetic, and controls the involuntary movement of the smooth muscles and glands of our organs.
Now, to better understand Lambert-Eaton myasthenic syndrome, let’s review normal skeletal muscle contraction at the cellular level.
First you’ve got your motor neurons, which have voltage-gated calcium channels in their membranes.
Whenever a motor neuron receives an electrical impulse from the brain, these channels open up and let calcium inside.
The increased intracellular calcium concentration triggers the release of small vesicles that contain the neurotransmitter acetylcholine into the neuromuscular junction.
Acetylcholine goes from the neuron over to the nicotinic receptors on muscle cell membranes.
Sources
- "Robbins Basic Pathology" Elsevier (2017)
- "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
- "Pathophysiology of Disease: An Introduction to Clinical Medicine 8E" McGraw-Hill Education / Medical (2018)
- "CURRENT Medical Diagnosis and Treatment 2020" McGraw-Hill Education / Medical (2019)
- "Available treatment options for the management of Lambert-Eaton myasthenic syndrome" Expert Opinion on Pharmacotherapy (2006)
- "Available treatment options for the management of Lambert-Eaton myasthenic syndrome" Expert Opinion on Pharmacotherapy (2006)
- "Lambert-Eaton Myasthenic Syndrome" Seminars in Neurology (2004)
Copyright © 2023 Elsevier, except certain content provided by third parties
Cookies are used by this site.
USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME). COMLEX-USA® is a registered trademark of The National Board of Osteopathic Medical Examiners, Inc. NCLEX-RN® is a registered trademark of the National Council of State Boards of Nursing, Inc. Test names and other trademarks are the property of the respective trademark holders. None of the trademark holders are endorsed by nor affiliated with Osmosis or this website.
