Langerhans cell histiocytosis
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Summary of Langerhans cell histiocytosis
Langerhans cell histiocytosis (LCH) is a rare disease involving clonal proliferation of Langerhans cells, dendritic cells of the skin. Clinically, its manifestations range from isolated bone lesions to multisystem disease.
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Hematological system
Pathology
Anemias
Iron deficiency anemia
Beta-thalassemia
Alpha-thalassemia
Sideroblastic anemia
Anemia of chronic disease
Lead poisoning
Hemolytic disease of the newborn
Glucose-6-phosphate dehydrogenase (G6PD) deficiency
Autoimmune hemolytic anemia
Pyruvate kinase deficiency
Paroxysmal nocturnal hemoglobinuria
Sickle cell disease (NORD)
Hereditary spherocytosis
Anemia of chronic disease
Aplastic anemia
Fanconi anemia
Megaloblastic anemia
Folate (Vitamin B9) deficiency
Vitamin B12 deficiency
Fanconi anemia
Diamond-Blackfan anemia
Heme synthesis disorders
Coagulation disorders
Platelet disorders
Mixed platelet and coagulation disorders
Thrombosis syndromes (hypercoagulability)
Lymphomas
Leukemias
Leukemoid reaction
Dysplastic and proliferative disorders
Plasma cell dyscrasias
Hematological system pathology review
Microcytic anemia: Pathology review
Non-hemolytic normocytic anemia: Pathology review
Intrinsic hemolytic normocytic anemia: Pathology review
Extrinsic hemolytic normocytic anemia: Pathology review
Macrocytic anemia: Pathology review
Heme synthesis disorders: Pathology review
Coagulation disorders: Pathology review
Platelet disorders: Pathology review
Mixed platelet and coagulation disorders: Pathology review
Thrombosis syndromes (hypercoagulability): Pathology review
Lymphomas: Pathology review
Leukemias: Pathology review
Plasma cell disorders: Pathology review
Myeloproliferative disorders: Pathology review
AssessmentsLangerhans cell histiocytosis
Langerhans cell histiocytosis
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Flashcards
Langerhans cell histiocytosis
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USMLE® Step 1 style questions USMLE
3 questions
USMLE® Step 2 style questions USMLE
1 questions
Preview
A 7-year-old boy is brought to the clinic by his mother because of severe left leg pain. He localizes the pain to the middle of his left thigh and rates it as a 9 on a 10-point scale with no radiation. He does karate and his family recently got a cat. He denies weight loss, night sweats, or recent trauma. Temperature is 37.3°C (99.2°F), blood pressure is 127/81 mm Hg, pulse is 76/min, respirations are 14/min. X-ray shows a lytic lesion in the mid-shaft of the left femur. Biopsy of the lesion is performed, and microscopic pathology shows numerous cells with clear nuclei and "coffee-bean" shaped nuclei, as well as areas of eosinophils. Which of the following is the most likely diagnosis?
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