Leukemoid reaction
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Leukemoid reaction
Blood and lymphoreticular system
Anemia, cytopenias, and polycythemia anemias
Acute intermittent porphyria
Porphyria cutanea tarda
Autoimmune hemolytic anemia
Glucose-6-phosphate dehydrogenase (G6PD) deficiency
Hemolytic disease of the newborn
Hereditary spherocytosis
Paroxysmal nocturnal hemoglobinuria
Pyruvate kinase deficiency
Sickle cell disease (NORD)
Fanconi anemia
Folate (Vitamin B9) deficiency
Megaloblastic anemia
Vitamin B12 deficiency
Alpha-thalassemia
Anemia of chronic disease
Beta-thalassemia
Iron deficiency anemia
Lead poisoning
Sideroblastic anemia
Anemia of chronic disease
Aplastic anemia
Diamond-Blackfan anemia
Fanconi anemia
Aplastic anemia
Immune thrombocytopenia
Leukemoid reaction
Polycythemia vera (NORD)
Coagulation disorders (hypercoaguable and hypocoaguable conditions)
Antiphospholipid syndrome
Antithrombin III deficiency
Factor V Leiden
Protein C deficiency
Protein S deficiency
Hemophilia
Vitamin K deficiency
Disseminated intravascular coagulation
Heparin-induced thrombocytopenia
Von Willebrand disease
Bernard-Soulier syndrome
Glanzmann's thrombasthenia
Hemolytic-uremic syndrome
Immune thrombocytopenia
Thrombotic thrombocytopenic purpura
Infectious and immunologic disorders
Neoplasms
Langerhans cell histiocytosis
Mastocytosis (NORD)
Essential thrombocythemia (NORD)
Myelodysplastic syndromes
Myelofibrosis (NORD)
Polycythemia vera (NORD)
Acute leukemia
Chronic leukemia
Hodgkin lymphoma
Non-Hodgkin lymphoma
Monoclonal gammopathy of undetermined significance
Multiple myeloma
Waldenstrom macroglobulinemia
Traumatic, mechanical, and vascular disorders
Blood and lymphoreticular system pathology review
Extrinsic hemolytic normocytic anemia: Pathology review
Heme synthesis disorders: Pathology review
Intrinsic hemolytic normocytic anemia: Pathology review
Macrocytic anemia: Pathology review
Microcytic anemia: Pathology review
Non-hemolytic normocytic anemia: Pathology review
Coagulation disorders: Pathology review
Mixed platelet and coagulation disorders: Pathology review
Platelet disorders: Pathology review
Thrombosis syndromes (hypercoagulability): Pathology review
Leukemias: Pathology review
Lymphomas: Pathology review
Myeloproliferative disorders: Pathology review
Plasma cell disorders: Pathology review
Assessments
Flashcards
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USMLE® Step 1 questions
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High Yield Notes
10 pages
Flashcards
Leukemoid reaction
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Questions
USMLE® Step 1 style questions USMLE
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A 47-year-old man comes to the office due to 2 days of sore throat, purulent nasal discharge and facial pain. Past medical history is significant for several sinus infections over the past 6 months, all of which resolved with oral antibiotics. Temperature is 38.5°C (101.4°F), pulse is 80/minute, respirations are 19/minute, and blood pressure is 130/70 mmHg. Physical examination shows pharyngeal erythema and maxillary sinus tenderness. There is no lymphadenopathy. Laboratory results are as follows:
Fluorescence in situ hybridization (FISH) analysis reveals a bcr-abl fusion gene. Which of the following additional findings is most likely to be seen in this patient?
| Laboratory value | Result |
| Complete blood count | |
| Hemoglobin | 10 g/dL |
| Platelets | 600,000/mm3 |
| Leukocytes | 100,100/mm3 |
| Neutrophils | 40% |
| Myelocytes | 32% |
| Metamyelocytes | 10% |
| Band forms | 1% |
| Blast cells | 1% |
| Lymphocytes | 7% |
External References
First Aid
2024
2023
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2021
Leukemoid reaction p. 209
Summary
Leukemoid reaction refers to an increase in white blood cell count, specifically above 50,000 cells/mm �, due to causes other than leukemia. Leukemoid reactions can occur as a response to stress or infection, and can mimic symptoms of leukemia, such as fatigue, weight loss, and bruising. Distinction between the two needs lab tests, which show elevated neutrophils (suggestive of an acute inflammatory process) in case of leukemoid reaction, and the absence of dysplastic cells (seen in leukemia).