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Generalized anxiety disorder
Social anxiety disorder
Major depressive disorder
Major depressive disorder with seasonal pattern
Premenstrual dysphoric disorder
Neuroleptic malignant syndrome
Lewy body dementia
Attention deficit hyperactivity disorder
Autism spectrum disorder
Disruptive, impulse control, and conduct disorders
Fetal alcohol syndrome
Body dysmorphic disorder
Body focused repetitive disorders
Cluster A personality disorders
Cluster B personality disorders
Cluster C personality disorders
Female sexual interest and arousal disorder
Genito-pelvic pain and penetration disorder
Male hypoactive sexual desire disorder
Somatic symptom disorder
Alcohol use disorder
Physical and sexual abuse
Post-traumatic stress disorder
Amnesia, dissociative disorders and delirium: Pathology review
Anxiety disorders, phobias and stress-related disorders: Pathology Review
Childhood and early-onset psychological disorders: Pathology review
Dementia: Pathology review
Developmental and learning disorders: Pathology review
Drug misuse, intoxication and withdrawal: Alcohol: Pathology review
Drug misuse, intoxication and withdrawal: Hallucinogens: Pathology review
Drug misuse, intoxication and withdrawal: Other depressants: Pathology review
Drug misuse, intoxication and withdrawal: Stimulants: Pathology review
Eating disorders: Pathology review
Malingering, factitious disorders and somatoform disorders: Pathology review
Mood disorders: Pathology review
Personality disorders: Pathology review
Psychiatric emergencies: Pathology review
Psychological sleep disorders: Pathology review
Schizophrenia spectrum disorders: Pathology review
Trauma- and stress-related disorders: Pathology review
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June & Tony's Story
Lewy Body Dementia
Lewy body dementia is a type of dementia, where individuals lose their memory and have difficulty learning new information.
Lewy bodies refers to protein deposits found inside neurons, and they’re named after Frederic Lewy, the neurologist who discovered them.
Lewy body dementia is a neurodegenerative disease, meaning that it worsens over time, and it’s the disease that afflicted comedian and actor Robin Williams.
The brain is made up of billions of neurons that communicate with each other by releasing neurotransmitters.
Most neurons in the cerebral cortex are called cholinergic neurons because they produce acetylcholine.
In contrast, neurons in a section of the midbrain called the substantia nigra are in charge of initiating movement and other motor functions.
These neurons are called dopaminergic because they produce dopamine.
The underlying cause of Lewy body dementia isn’t well understood.
Normally, neurons contain a protein called alpha synuclein, and in Lewy body dementia, this protein gets misfolded within the neurons.
The misfolded alpha-synuclein aggregates to form Lewy bodies that deposit inside neurons, particularly in the cortex and the substantia nigra.
Under a microscope, Lewy bodies look like dark, eosinophilic inclusions inside the affected neurons.
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