Transcription of DNA
Translation of mRNA
Amino acids and protein folding
Protein structure and synthesis
DNA damage and repair
Mitosis and meiosis
Adenosine deaminase deficiency
Acute radiation syndrome
Purine and pyrimidine synthesis and metabolism disorders: Pathology review
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Li-Fraumeni syndrome p. 222
osteosarcomas p. 474
tumor suppressor genes in p. 222
Li-Fraumeni syndrome (LFS) is a rare inherited genetic disorder. People with Li-Fraumeni syndrome have an increased risk of developing multiple malignancies, typically sarcoma, breast carcinoma, leukemia, and adrenocortical carcinoma cancer.
In this condition, cancers often develop cancer at a young age and people are also more likely to have multiple tumors than people without this syndrome. The cause of Li-Fraumeni syndrome is a mutation in the p53 tumor suppressor gene. This gene provides instructions for making a protein that regulates the cell cycle and prevents genomic mutations that might lead to these cancers.
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