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Organ system histology
Lymph node histology
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Lymphoid tissue and organs contain a lot of lymphocytes and other white blood cells.
The primary lymphoid organs include the thymus and bone marrow.
They’re encapsulated, bean-shaped structures that usually have a diameter of about 1 cm along the short axis and 2.5 cm along the long axis.
And they support the immune system by filtering the lymph, in order to identify and fight infections.
If we zoom closer, we can more easily identify the outer capsule of connective tissue, as well as the three functional regions of the lymph node.
The germinal center is where B cells differentiate into plasma cells.
The next region is the inner cortex or paracortex, which doesn’t have any nodules.
And finally, the innermost region of the lymph node is the medulla.
The distinction between the inner cortex and medulla is hard to see at this magnification, but the medulla will have cords of lymphoid tissue, as well as passageways for lymph called medullary sinuses.
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