Malassezia (Tinea versicolor and Seborrhoeic dermatitis)

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Summary of Malassezia (Tinea versicolor and Seborrhoeic dermatitis)

Malassezia species, formerly known as Pityrosporum are members of human cutaneous commensal flora, which are associated with a wide spectrum of clinical manifestations from benign skin conditions, such as tinea versicolor, to fungemia in the immunocompromised host.

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Malassezia (Tinea versicolor and Seborrhoeic dermatitis)

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NOTES NOTES CUTANEOUS FUNGAL INFECTIONS GENERALLY, WHAT ARE THEY? DIAGNOSIS PATHOLOGY & CAUSES ▪ Noninvasive fungal infections of skin and its annexes ▫ Limited to stratum corneum ▫ Caused by human skin’s commensal ﬂora LAB RESULTS ▪ Microscopic observation OTHER DIAGNOSTICS ▪ Clinical ﬁndings upon examination SIGNS & SYMPTOMS ▪ Skin pigmentation changes ▪ Characteristic lesions: macule, patch, scale, plaque ▪ Occasional pruritus TREATMENT MEDICATIONS ▪ Antifungal MALASSEZIA (TINEA VERSICOLOR & SEBORRHOEIC DERMATITIS) osms.it/malassezia PATHOLOGY & CAUSES ▪ Genus of yeast-like fungi ▪ Cause cutaneous infections ▪ Cutaneous commensal ﬂora, mostly lipiddependent (thrive on human sebum), saprophytic (nutrients obtained from dead, organic matter), dimorphic (yeast, hyphal/ mycelial forms) 366 OSMOSIS.ORG TYPES Tinea versicolor ▪ Superﬁcial cutaneous mycosis ▪ AKA pityriasis versicolor ▪ Most common causes: M. globosa, M. furfur, M. sympodialis ▪ Fungus produces azelaic acid → tyrosinase activity (activated by sunlight) → skin pigmentation changes → hypopigmented/ hyperpigmented macules, patches, plaques

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Malassezia (Tinea versicolor and Seborrhoeic dermatitis)

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A 22-year-old male comes to the clinic with mildly pruritic, depigmented skin lesions on his back. He says that it started with a few patches, but now it has spread across his whole back. He first noticed it after returning from spring break in the Bahamas. He has no other specific complaints and the rest of his past medical history is unremarkable. Physical examination shows small, hypopigmented, scaling macules on his back. Which of the following will most likely be seen on microscopic imaging of a skin lesion?

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