00:00 / 00:00
0 / 11 complete
0 / 2 complete
rubeola p. 167, 178, 183
rubeola p. 167
rubeola p. 167
paramyxovirus p. 164, 166
presentation p. 716
unvaccinated children p. 183
vitamin A for p. 64
measles p. 166
measles p. 167
The reason why this guy’s so contagious is that it’s airborne, and spreads via tiny liquid particles that get flung into the air when someone sneezes or coughs, and can live for up to two hours in that airspace or nearby surfaces.
If someone breathes in that air or touches a surface and then touches their eyes, their eyes, or their mouths, they can become infected.
Measles is so contagious that if one person has it, 90% of nearby non-immune people will also become infected.
Measles virus uses a protein on its surface called hemagglutinin, or just H protein, to bind to a target receptor on the host cell, which could be CD46, which is expressed on all nucleated human cells, CD150, aka signaling lymphocyte activation molecule or SLAM, which is found on immune cells like B or T cells, and antigen-presenting cells, or nectin-4, a cellular adhesion molecule.
Once bound, the fusion, or F protein helps the virus fuse with the membrane and ultimately get inside the cell.
Now this virus is a single-stranded RNA virus, and it’s also a negative sense, meaning it first has to be transcribed by RNA polymerase into a positive-sense mRNA strand.
After that it’s ready to be translated into viral proteins, wrapped in the cell’s lipid envelope, and sent out of the cell as a newly made virus.
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