Skip to content

Megaloblastic anemia

Summary of Megaloblastic anemia
Megaloblastic anemia results from inhibition of DNA synthesis during red blood cell production. When DNA synthesis is impaired, the cell cycle cannot progress through the cell cycle properly, leading to cell growth without division, which presents as macrocytosis. Megaloblastic anemia has a rather slow onset, especially when compared to that of other anemias. The defect in red blood cell DNA synthesis is most often due to a deficiency of vitamin B12 and/or folic acid. 

Videos

Notes

Hematological system

Pathology

Anemias
Heme synthesis disorders
Coagulation disorders
Platelet disorders
Mixed platelet and coagulation disorders
Thrombosis syndromes (hypercoagulability)
Lymphomas
Leukemias
Leukemoid reaction
Dysplastic and proliferative disorders
Plasma cell dyscrasias
Hematological system pathology review

Assessments
Megaloblastic anemia

Flashcards

0 / 27 complete

Questions

1 / 5 complete
High Yield Notes
4 pages
Flashcards

Megaloblastic anemia

27 flashcards
Preview

are the two most common causes of megaloblastic anemia.

Questions

USMLE® Step 1 style questions USMLE

4 questions

USMLE® Step 2 style questions USMLE

4 questions
Preview

A 25-year-old man comes to his primary care physician's office because of weakness and fatigue for the past 2 months. The patient also reports recent sensations of pins and needles in his lower extremities. Physical examination shows conjunctival pallor and atrophic glossitis. Laboratory results show a hemoglobin level of 9.0 g/dl and a mean corpuscular volume of 110 fl/red cell. Which of the following vitamin deficiencies may lead to megaloblastic anemia?

External References